Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives
Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives
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DOI：
10.1016/j.contraception.2006.03.022
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发表时间：
2006-09-01
期刊：
影响因子：
2.9
通讯作者：
Cagiano, Raffaele
中科院分区：
文献类型：
--
作者：
Sabatini, Rosa;Cagiano, Raffaele
目的：本研究的目的是比较周期控制，耐受性和性健康与使用三种激素避孕药。方法：在本前瞻性随机研究中，比较两种联合口服避孕药[20 μ g炔雌醇/100 μ g左炔诺孕酮和15 μ g炔雌醇/60 μ g孕酮]与阴道环（15 μ g炔雌醇/120 μ g炔诺孕酮）的效果。研究人员获得了280名女性一年的数据。我们调查了月经周期的模式和体重增加、恶心、头痛、乳房压痛、恶心、抑郁和阴道干燥的发生率。此外，还对性欲和性满意度进行了评估。最后，估计三组患者的累计停药率。结论：对不良事件的分析揭示了可接受性、依从性和继续治疗的两个关键点：阴道干燥、性欲丧失引起的周期控制不良和性交障碍。(c) 2006爱思唯尔公司版权所有。
Objective: The objective of this study was to compare cycle control, tolerability and sexual well-being with the use of three hormonal contraceptives.Methods: In this prospective randomized study, the effects of two combined oral contraceptives [20 mu g of ethinylestradiol (EE)/100 mu g of levonorgestrel and 15 mu g of EE/60 mu g of gestodene] were compared with those of the vaginal ring (15 mu g of EE/120 mu g of etonogestrel). One-year data from 280 women were obtained. We investigated the pattern of menstrual cycle and the incidence of weight gain, nausea, headache, breast tenderness, initability, depression and vaginal dryness. Moreover, desire and sexual satisfaction were evaluated. Finally, the cumulative rate of discontinuation in the three groups was estimated.Conclusion: The analysis of adverse events revealed two crucial points for acceptability, compliance and continuation: poor cycle control and disturbance of sexual intercourse due to vaginal dryness and loss of desire. (c) 2006 Elsevier Inc. All rights reserved.