Fabrication of three-lobed magnetic microrobots for cell transportation
Fabrication of three-lobed magnetic microrobots for cell transportation
复制标题
用于细胞运输的三叶磁性微型机器人的制造
DOI：
10.1039/d3tb00613a
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发表时间：
2023
影响因子：
7
通讯作者：
Das, Sambeeta
中科院分区：
文献类型：
--
作者：
Shah, Zameer Hussain;Sokolich, Max;Mallick, Sudipta;Rivas, David;Das, Sambeeta
移动微型机器人有可能改变基于治疗性交付的医疗。具体地说，微型机器人在细胞治疗中是很有希望的细胞运输候选者。尽管微型机器人在细胞操纵方面最近取得了进展，但仍有必要设计和制造微型机器人来进一步推动这一领域的发展。在这项工作中，我们提出了一种简单的方法来制造三叶微型机器人的工作台程序。微型机器人由无害的磁场驱动，这使它们变得更具生物友好性。在化学上，这些微型机器人是由有机硅制成的。微型机器人在开环和闭环设置下都显示出同样好的控制效果。在开环控制实验中，三叶微机器人有两种运动方式。我们将这两种模式用于单细胞传输。我们的结果表明，三叶微型机器人在流体中的细胞传输方面非常有前途。
Mobile microrobots have the potential to transform medical treatments based on therapeutic delivery. Specifically, microrobots are promising candidates for cell transportation in cell-based therapies. Despite recent progress in cellular manipulation by microrobots, there is a significant need to design and fabricate microrobots to advance the field further. In this work, we present a facile approach to manufacturing three-lobed microrobots by a bench-top procedure. The microrobots are actuated by a harmless magnetic field which makes them biofriendly. Chemically, these microrobots are made of organosilica. The microrobots showed equally good control in both the open-loop and closed-loop settings. The three-lobed microrobots have two modes of motion during the open-loop control experiments. We employed these two modes for single-cell transportation. Our results show that the three-lobed microbots are very promising for cell transportation in a fluid.