Finger somatotopy in human motor cortex
Finger somatotopy in human motor cortex
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DOI：
10.1006/nimg.2000.0737
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发表时间：
2001-06-01
期刊：
影响因子：
5.7
通讯作者：
Deecke, L
中科院分区：
文献类型：
--
作者：
Beisteiner, R;Windischberger, C;Deecke, L
尽管存在关于人类运动皮层中手指体位表征的定性报告，但到目前为止还没有研究可以提供明确的统计证据。本研究的目的是通过对右手食指和小指的标准化运动进行彻底研究来重新研究手指运动躯体学。使用 3 特斯拉的高分辨率 fMRI，重复测量 26 名受试者的血氧水平依赖性 (BOLD) 反应，以获得可靠的统计结果。对于每个手指和每次运行，计算初级运动皮层内所有激活体素的质心。对所有运行的结果进行平均，以产生每个受试者的单独食指和小指代表。然后将所有受试者的平均质量中心定位进行配对 t 检验。结果显示，按 Penfields 运动小人所指示的顺序，手指特异性激活模式虽然规模较小，但具有高度显着性。此外，还发现了手指特异性 BOLD 反应的相当大的重叠。比较各种分析方法，两个手指的平均质心距离在包含重叠体素的情况下为 2-3 毫米，在排除重叠体素的情况下为 4-5 毫米。我们的数据可能在 Schieber (1999) 的工作背景下得到最好的理解，他最近描述了人类病变研究中重叠的体位梯度。 (C) 2001 年学术出版社。
Although qualitative reports about somatotopic representation of fingers in the human motor cortex exist, up to now no study could provide clear statistical evidence. The goal of the present study was to reinvestigate finger motor somatotopy by means of a thorough investigation of standardized movements of the index and little finger of the right hand. Using high resolution fMRI at 3 Tesla, blood oxygenation level-dependent (BOLD) responses in a group of 26 subjects were repeatedly measured to achieve reliable statistical results. The center of mass of all activated voxels within the primary motor cortex was calculated for each finger and each run. Results of all runs were averaged to yield an individual index and little finger representation for each subject. The mean center of mass localizations for all subjects were then submitted to a paired t test. Results show a highly significant though small scale somatotopy of fingerspecific activation patterns in the order indicated by Penfields motor homunculus, In addition, considerable overlap of finger specific BOLD responses was found. Comparing various methods of analysis, the mean center of mass distance for the two fingers was 2-3 mm with overlapping voxels included and 4-5 mm with overlapping voxels excluded. Our data may be best understood in the context of the work of Schieber (1999) who recently described overlapping somatotopic gradients in lesion studies with humans. (C) 2001 Academic Press.