Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study.
Epigenetic Aging Is Associated With Measures of Midlife Muscle Volume and Attenuation in CARDIA Study.
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CARDIA 研究中表观遗传衰老与中年肌肉体积和衰减的测量相关。
DOI：
10.1093/gerona/glad261
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
Gao,Tao;Zheng,Yinan;Joyce,BrianT;Kho,Minjung;Terry,JamesG;Wang,Jun;Nannini,Drew;Carr,JohnJeffrey;Nair,Sangeeta;Zhang,Kai;Zhao,Wei;JacobsJr,DavidR;Schreiner,PamelaJ;Greenland,Philip;Lloyd-Jones,Donald;Smith,JenniferA;
研究背景年龄加速度（GAA）是一种代表生理性衰老的表观遗传标记，与年龄相关疾病如癌症、心血管疾病等密切相关。然而，GAA和肌肉质量和功能之间的关联是unknow.MethodsWe估计的措施GAA在1 118黑色和白色参与者的冠状动脉风险发展在年轻人（CARDIA）研究在考试年（Y）15（2000-2001）和20（2005-2006）。在Y25（2010-2011）访视时使用CT扫描测量腹肌组成。我们采用多元回归模型来研究协会的GAA估计与肌肉成像measurements.ResultsIn的心脏研究，每1年更高的GAA与平均1.1%（95%置信区间[CI]：0.6%，1.5%）更高的肌间脂肪组织（IMAT）量的腹部肌肉。GAA每增加1年，平均瘦肌衰减降低-0.089 Hounsfield单位（HU; 95% CI：-0.146，-0.032），腹部肌肉平均IMAT衰减降低-0.049 HU（95% CI：-0.092，-0.007）。分层分析表明，GAA是更强的相关性较高的腹部肌肉IMAT体积的女性和显着相关的较低的瘦肌肉衰减白色participants only.ConclusionsHigher GAA与较高的腹部肌肉IMAT体积和较低的瘦肌肉衰减在中年人口。
BackgroundGrimAge acceleration (GAA), an epigenetic marker that represents physiologic aging, is associated with age-related diseases including cancer and cardiovascular diseases. However, the associations between GAA and muscle mass and function are unknown.MethodsWe estimated measures of GAA in 1 118 Black and White participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Study at exam years (Y) 15 (2000–2001) and 20 (2005–2006). Abdominal muscle composition was measured using CT scans at the Y25 (2010–2011) visit. We used multivariate regression models to examine associations of GAA estimates with muscle imaging measurements.ResultsIn the CARDIA study, each 1-year higher GAA was associated with an average 1.1% (95% confidence interval [CI]: 0.6%, 1.5%) higher intermuscular adipose tissue (IMAT) volume for abdominal muscles. Each 1-year higher GAA was associated with an average −0.089 Hounsfield unit (HU; 95% CI: −0.146, −0.032) lower lean muscle attenuation and an average −0.049 HU (95% CI: −0.092, −0.007) lower IMAT attenuation for abdominal muscles. Stratified analyses showed that GAA was more strongly associated with higher abdominal muscle IMAT volume in females and significantly associated with lower lean muscle attenuation for White participants only.ConclusionsHigher GAA is associated with higher abdominal muscle IMAT volume and lower lean muscle attenuation in a midlife population.
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内皮素：一种新型心血管调节肽。
影响因子：
8.9
作者：
A. Lerman;F. Hildebrand;K. Margulies;B. O’Murchu;M. Perrella;D. Heublein;T. Schwab;J. Burnett
通讯作者：
J. Burnett
影响因子：
3
作者：
T. Masaki
通讯作者：
T. Masaki
犬动脉和静脉对内皮素的敏感性不同。
DOI：
10.1152/ajpheart.1989.257.4.h1127
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Miller,VM;Komori,K;BurnettJr,JC;Vanhoutte,PM
通讯作者：
Vanhoutte,PM
内皮素-1在体内和体外实验中的正性肌力和血管收缩作用：L型钙通道的特征和作用
影响因子：
3
作者：
Toshifumi Watanabe;K. Kusumoto;T. Kitayoshi;N. Shimamoto
通讯作者：
N. Shimamoto
DOI：
10.1016/0006-291x(89)92636-3
发表时间：
1989-06-15
影响因子：
3.1
作者：
CERNACEK, P;STEWART, DJ
通讯作者：
STEWART, DJ