Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder:: Association with higher body mass index
Investigation of 3111T/C polymorphism of the CLOCK gene in obese individuals with or without binge eating disorder:: Association with higher body mass index
复制标题
DOI：
10.1016/j.neulet.2008.02.003
复制
发表时间：
2008-04-11
影响因子：
2.5
通讯作者：
Maj, Mario
中科院分区：
文献类型：
--
作者：
Monteleone, Palmiero;Tortorella, Alfonso;Maj, Mario
代谢相关功能的昼夜节律模式的丧失似乎在肥胖的发病机制中起作用；因此，我们有理由推测（Circadian locomotor output cycles kaput） CLOCK基因的功能性3111T/C单核苷酸多态性（SNP）可能与肥胖的遗传易感性有关。本研究的目的是评估有或没有暴食症（BED）的超重/肥胖受试者与正常体重健康对照者相比，3111T/C CLOCK基因SNP的频率。共284名高加索人参与研究，其中体重正常健康者92名，超重/肥胖患者192名（BED患者107名）。基因型和等位基因频率在正常体重对照和超重/肥胖患者（伴有和/或不伴有BED）之间没有显著差异。然而，携带CC基因型的超重/肥胖患者的体重指数（BMI）值明显高于携带CT和/或TT基因型的患者。此外，与BMI < 40 kg/m的个体相比，肥胖III类个体CC基因型和C等位基因的频率显著更高(2)。目前的研究结果首次表明，CLOCK基因的3111T/C SNP与人类肥胖和/或BED无关，但它似乎使肥胖个体易患更高的BMI。2008爱思唯尔爱尔兰有限公司版权所有。
Loss of circadian patterning of metabolism-related functions seems to play a role in the pathogenesis of obesity; therefore, it is reasonable to hypothesize that the functional 3111T/C single nucleotide polymorphism (SNP) of the (Circadian locomotor output cycles kaput) CLOCK gene may have a part in the genetic susceptibility to obesity. The aim of this study was to assess the frequencies of 3111T/C CLOCK gene SNP in overweight/obese subjects with or without binge eating disorder (BED) as compared to normal weight healthy controls. A total of 284 Caucasian subjects, including 92 normal weight healthy subjects and 192 overweight/obese patients (107 with BED) participated into the study. Genotype and allele frequencies did not significantly differ between normal weight controls and overweight/obese patients with and/or without BED. However, overweight/obese patients carrying the CC genotype had significantly higher values of body mass index (BMI) as compared to those carrying the CT and/or TT genotypes. Moreover, obese class III individuals had a significantly higher frequency of both the CC genotype and the C allele as compared to individuals with BMI < 40 kg/m(2). Present findings show for the first time that the 3111T/C SNP of the CLOCK gene is not associated to human obesity and/or BED, but it seems to predispose obese individuals to a higher BMI. (C) 2008 Elsevier Ireland Ltd. All rights reserved.