Anilide Formation from Thioacids and Perfluoroaryl Azides
Anilide Formation from Thioacids and Perfluoroaryl Azides
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DOI：
10.1021/acs.joc.5b00240
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发表时间：
2015-05-01
影响因子：
3.6
通讯作者：
Yan, Mingdi
中科院分区：
文献类型：
--
作者：
Xie, Sheng;Fukumoto, Ryo;Yan, Mingdi
介绍了一种由全氟芳基叠氮化物和硫代酸快速、清洁生成苯胺的无金属方法。实验证明，该反应具有反应速度快、收率高、化学选择性好等特点。该转化物与多种溶剂兼容，对多种官能团具有耐受性，在极性质子/非质子介质中表现出良好的性能，包括水缓冲体系。
A metal-free method for fast and clean anilide formation from perfluoroaryl azide and thioacid is presented. The reaction proved highly efficient, displaying fast kinetics, high yield, and good chemoselectivity. The transformation was compatible with various solvents and tolerant to a wide variety of functional groups, and it showed high performance in polar protic/aprotic media, including aqueous buffer systems.