The neural basis of central proprioceptive processing in older versus younger adults: An important sensory role for right putamen
The neural basis of central proprioceptive processing in older versus younger adults: An important sensory role for right putamen
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DOI：
10.1002/hbm.21257
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发表时间：
2012-04-01
影响因子：
4.8
通讯作者：
Swinnen, Stephan P.
中科院分区：
文献类型：
--
作者：
Goble, Daniel J.;Coxon, James P.;Swinnen, Stephan P.
我们对身体位置和运动的感觉独立于视觉（即，本体感觉）依赖于肌梭反馈并且对于执行运动动作是至关重要的。在这项研究中，我们首先试图阐明与年龄相关的差异，通过刺激足部肌梭和功能性磁共振成像测量神经激活的本体感受信息的中枢处理。我们发现，健康的老年人在振动诱导的肌梭刺激过程中激活了与年轻人相似的初级体感和次级联想皮层脑区的分布式网络。与年轻年龄组相比，老年组的右壳核体素簇中的神经活动也显着减少。鉴于这些差异，我们在每组中进行了两项额外的分析，量化了年龄依赖性活动与（1）大脑结构和（2）本体感受能力的行为测量的相关程度。使用扩散张量成像，老年人（而不是年轻人）与较高的平均分数各向异性的成年人被发现有增加的右壳核神经活动。在肌腱振动过程中观察到的依赖性右壳核活动也与测量年轻和老年组踝关节位置感的本体感受能力的行为测试相关。偏相关检验表明，老年人关节位置觉与右壳核神经活动之间的关系是由大脑结构介导的，而不是相反。这些结果表明，右壳核内的结构差异与老年人的激活减少有关，并可能作为老年人本体感觉敏感性的生物标志物。^Brain Mapp，2012. (c)2011 Wiley Periodicals，Inc.
Our sense of body position and movement independent of vision (i.e., proprioception) relies on muscle spindle feedback and is vital for performing motor acts. In this study, we first sought to elucidate age-related differences in the central processing of proprioceptive information by stimulating foot muscle spindles and by measuring neural activation with functional magnetic resonance imaging. We found that healthy older adults activated a similar, distributed network of primary somatosensory and secondary-associative cortical brain regions as young individuals during the vibration-induced muscle spindle stimulation. A significant decrease in neural activity was also found in a cluster of right putamen voxels for the older age group when compared with the younger age group. Given these differences, we performed two additional analyses within each group that quantified the degree to which age-dependent activity was related to (1) brain structure and (2) a behavioral measure of proprioceptive ability. Using diffusion tensor imaging, older (but not younger) adults with higher mean fractional anisotropy were found to have increased right putamen neural activity. Age-dependent right putamen activity seen during tendon vibration was also correlated with a behavioral test of proprioceptive ability measuring ankle joint position sense in both young and old age groups. Partial correlation tests determined that the relationship between elderly joint position sense and neural activity in right putamen was mediated by brain structure, but not vice versa. These results suggest that structural differences within the right putamen are related to reduced activation in the elderly and potentially serve as biomarker of proprioceptive sensibility in older adults. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.