Positive effects of neurofeedback on autism symptoms correlate with brain activation during imitation and observation
Positive effects of neurofeedback on autism symptoms correlate with brain activation during imitation and observation
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DOI：
10.1111/ejn.13551
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发表时间：
2018-03-01
影响因子：
3.4
通讯作者：
Mueller, Ralph-Axel
中科院分区：
文献类型：
--
作者：
Datko, Michael;Pineda, Jaime A.;Mueller, Ralph-Axel
Autism has been characterized by atypical task-related brain activation and functional connections, coinciding with deficits in sociocommunicative abilities. However, evidence of the brain's experience-dependent plasticity suggests that abnormal activity patterns may be reversed with treatment. In particular, neurofeedback training (NFT), an intervention based on operant conditioning resulting in self-regulation of brain electrical oscillations, has shown increasing promise in addressing abnormalities in brain function and behavior. We examined the effects of 20h of sensorimotor mu-rhythm-based NFT in children with high-functioning autism spectrum disorders (ASD) and a matched control group of typically developing children (ages 8-17). During a functional magnetic resonance imaging imitation and observation task, the ASD group showed increased activation in regions of the human mirror neuron system following the NFT, as part of a significant interaction between group (ASD vs. controls) and training (pre- vs. post-training). These changes were positively correlated with behavioral improvements in the ASD participants, indicating that mu-rhythm NFT may be beneficial to individuals with ASD.
