Peripheral blood concentrations of adiponectin, an adipocyte-specific plasma protein, in normal pregnancy and preeclampsia
Peripheral blood concentrations of adiponectin, an adipocyte-specific plasma protein, in normal pregnancy and preeclampsia
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DOI：
10.1016/j.jri.2004.09.004
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发表时间：
2005-02-01
影响因子：
3.4
通讯作者：
Morikawa, H
中科院分区：
文献类型：
--
作者：
Naruse, K;Yamasaki, M;Morikawa, H
胰岛素抵抗在正常妊娠过程中增加，被认为是妊娠期糖尿病、妊娠高血压和先兆子痫（PE）等并发症的重要原因。脂联素，一种脂肪细胞特异性血浆蛋白，被认为可以增强胰岛素敏感性；另一种脂肪细胞因子，瘦素，也被认为能促进胰岛素敏感性。我们测定了40名身体质量指数（BMI）相同的健康非孕妇外周血脂联素和瘦素的浓度。
Insulin resistance increases during the normal course of pregnancy, and is considered an important cause of complications including gestational diabetes mellitus, pregnancy-induced hypertension and preeclampsia (PE). Adiponectin, an adipocyte-specific plasma protein, is thought to enhance insulin sensitivity; another adipocytokine, leptin, also is thought to promote insulin sensitivity. We determined peripheral blood concentrations of adiponectin and leptin in 40 healthy nonpregnant women with a body mass index (BMI)