Influence of Ovarian Endometrioma on Expression of Steroid Receptor RNA Activator, Estrogen Receptors, Vascular Endothelial Growth Factor, and Thrombospondin 1 in the Surrounding Ovarian Tissues
Influence of Ovarian Endometrioma on Expression of Steroid Receptor RNA Activator, Estrogen Receptors, Vascular Endothelial Growth Factor, and Thrombospondin 1 in the Surrounding Ovarian Tissues
复制标题
卵巢子宫内膜异位瘤对卵巢周围组织中类固醇受体RNA激活剂、雌激素受体、血管内皮生长因子和血小板反应蛋白1表达的影响
DOI：
10.1177/1933719113492205
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发表时间：
2014-02-01
影响因子：
2.9
通讯作者：
Lin, Jun
中科院分区：
文献类型：
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作者：
Lin, Kaiqing;Ma, Junyan;Lin, Jun
本研究探讨卵巢子宫内膜瘤对卵巢周围组织中类固醇受体RNA激活剂（SRA）、雌激素受体（ERs）、血管内皮生长因子（VEGF）和血小板反应蛋白1 （TSP-1）表达的影响。采用实时聚合酶链反应和Western blot对腹腔镜下卵巢子宫内膜异位瘤和成熟畸胎瘤患者的活检结果进行分析。结果表明，子宫内膜瘤周围卵巢组织的SRA和ER-α水平低于子宫内膜瘤，而SRA蛋白（SRAP）和ER-β水平高于子宫内膜瘤。卵巢子宫内膜异位瘤组卵巢周围组织中SRA、SRAP、ER-α和ER-β的表达水平较对照组高，VEGF水平较低，TSP-1水平较高。这些数据表明卵巢子宫内膜异位瘤使卵巢周围组织中SRA、er和TSP-1升高，而使VEGF水平降低，提示这些分子的异常表达可能影响卵巢子宫内膜异位瘤的生物学行为。
This study investigates the influence of ovarian endometrioma on expression of steroid receptor RNA activator (SRA), estrogen receptors (ERs), vascular endothelial growth factor (VEGF), and thrombospondin 1 (TSP-1) in the surrounding ovarian tissues. Taken from the women with ovarian endometrioma and mature teratoma during laparoscopy, the biopsies were analyzed by real-time polymerase chain reaction and Western blot. Our results indicated that ovarian tissues surrounding endometrioma had lower SRA and ER-α levels but higher SRA protein (SRAP) and ER-β levels than ovarian endometrioma. With lower VEGF levels and higher TSP-1 levels, the surrounding ovarian tissues showed higher expression levels of SRA, SRAP, ER-α, and ER-β in the ovarian endometrioma group when compared to the controls. These data showed that ovarian endometrioma increases SRA, ERs, and TSP-1 but decreases VEGF levels in the surrounding ovarian tissues, suggesting that abnormal expression of these molecules may affect biological behaviors of ovarian endometrioma.