Is Pentraxin 3 Involved in Obesity-Induced Decrease in Arterial Distensibility
Is Pentraxin 3 Involved in Obesity-Induced Decrease in Arterial Distensibility
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DOI：
10.5551/jat.2741
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发表时间：
2010-01-01
影响因子：
4.4
通讯作者：
Ajisaka, Ryuichi
中科院分区：
文献类型：
--
作者：
Miyaki, Asako;Maeda, Seiji;Ajisaka, Ryuichi
目的：肥胖是心血管疾病发病率和死亡率的重要危险因素。此外，中心动脉扩张性降低被认为是心血管疾病（CVD）的独立危险因素。肥胖受试者表现出低动脉扩张性;然而，肥胖受试者动脉扩张性降低的机制尚未阐明。正五聚蛋白3（PTX 3）是最近鉴定的正五聚蛋白家族的成员，在动脉粥样硬化区域产生。最近的一项研究表明，PTX 3水平可能指示血管炎症状态。方法：11名肥胖男性（年龄：44 +/-2岁，体重指数[BMI]：32 +/-1 kg/m2）和14名非肥胖男性（年龄：42 +/-2岁，BMI：26 +/-1 kg/m2）参与了本研究。我们测量动脉顺应性（同时使用B型超声和颈总动脉压平张力计）; β-刚度指数，动脉顺应性指数调整膨胀压力;和血浆PTX 3 concentration.Results：动脉顺应性显着降低，β-刚度指数显着高于肥胖男性比非肥胖男性。血浆PTX 3浓度显着高于肥胖比non-obese men.Conclusions：肥胖男性有较低的动脉扩张性和较高的循环PTX 3水平比非肥胖男性，因此，较高的PTX 3水平和降低动脉扩张性共存于肥胖男性。肥胖男性中高浓度的PTX 3可能参与了肥胖诱导的动脉扩张性降低的机制。
Aim: Obesity is a strong risk factor for cardiovascular morbidity and mortality. In addition, decreased central arterial distensibility is recognized as an independent risk factor for cardiovascular disease (CVD). Obese subjects exhibit low arterial distensibillity; however, the mechanism responsible for the decrease in arterial distensibility in obese subjects has not yet been elucidated. Pentraxin 3 (PTX3), a recently identified member of the pentraxin family of proteins, is produced in areas of atherosclerosis. A recent study has revealed that the PTX3 level may indicate the vascular inflammatory status. The aim of this study was to investigate plasma PTX3 concentrations and arterial distensibility in obese subjects.Methods: Eleven obese men (age: 44 +/- 2 years, body mass index [BMI]: 32 +/- 1 kg/m(2)) and 14 non-obese men (age: 42 +/- 2 years, BMI: 26 +/- 1 kg/m(2)) participated in this study. We measured arterial compliance (using simultaneous B-mode ultrasound and arterial applanation tonometry of the common carotid artery); beta-stiffness index, an index of arterial compliance adjusted for distending pressure; and plasma PTX3 concentrations.Results: Arterial compliance was significantly lower and the beta-stiffness index was significantly higher in obese men than in non-obese men. Plasma PTX3 concentration was markedly higher in obese than non-obese men.Conclusions: Obese men have lower arterial distensibility and higher circulating PTX3 levels than non-obese men; therefore, higher PTX3 levels and decreased arterial distensibility coexist in obese men. The high PTX3 concentrations in obese men may be involved in the mechanism underlying the obesity-induced decrease in arterial distensibility.