Potential impact of a predictive test on the gene frequency of Huntington disease.
Potential impact of a predictive test on the gene frequency of Huntington disease.
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预测测试对亨廷顿病基因频率的潜在影响。
DOI：
10.1002/ajmg.1320180311
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Clark,E
中科院分区：
文献类型：
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作者：
Schoenfeld,M;Myers,RH;Berkman,B;Clark,E
55名有50%亨廷顿病(HD)遗传风险的人接受了深入的结构化采访，以调查对使用预测性测试的态度，并评估此类测试对出生基因携带者数量的可能影响。四分之三的受访者表示，他们将接受预测性测试。如果有阳性预测或产前测试，选择生育孩子的个体数量从总样本的80%减少到42%，或者说减少了近一半。有很大比例的高危个人表示他们将使用预测性测试，这突显了在实施之前为其管理制定指导方针的重要性。
Fifty‐five individuals at 50% risk of inheriting Huntington disease (HD) were given in‐depth structured interviews to survey attitudes toward use of a predictive test and to assess the possible impact of such a test on the number of gene carriers born. Three‐quarters of the sample said they would take predictive test. Given a positive predictive or prenatal test, the number of individuals choosing to have children is reduced from 80% of the total sample to 42%, or by almost one‐half. The large proportion of at risk individuals who say they would use a predictive test underscores the importance of developing guidelines for its administration prior to implementation.