Encyclopedia of Behavioral Medicine
Encyclopedia of Behavioral Medicine
复制标题
行为医学百科全书
DOI：
10.1007/978-1-4614-6439-6_101903-1
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Trim W
中科院分区：
文献类型：
--
作者：
Trim W
正常脂肪组织功能受损，其特征是组织微环境的结构和细胞组成发生变化，导致主要但不完全来自脂肪细胞（即脂肪细胞）和局部免疫细胞的异常分泌物。这些变化可能是由能量不平衡引起的，并且通常在衰老和肥胖中观察到。结果是腹部皮下和内脏（腹内）脂肪组织扩张，但对于女性来说，尤其是臀股（臀部和腿部）脂肪储存。更广泛的后果是局部和全身炎症、组织特异性和全身胰岛素敏感性受损以及代谢控制不良。因此，脂肪组织功能障碍与II型糖尿病、高血压、癌症、认知功能障碍和动脉粥样硬化的发病机制有关。
The impairment of normal adipose tissue function, characterized by changes to the structure and cellular composition of the tissue microenvironment, resulting in abnormal secretions derived predominantly, but not exclusively, from adipocytes (ie, fat cells) and localized immune cells. These changes can be instigated by energy imbalance and are commonly observed with aging and obesity. The result is expansion of abdominal subcutaneous and visceral (intra-abdominal) adipose tissue, but for women, especially, gluteofemoral (hip and legs) adipose stores. The broader consequences are local and systemic inflammation, impaired tissue-specific and whole-body insulin sensitivity, and poor metabolic control. Thus, adipose tissue dysfunction is implicated in the pathogenesis of type-II diabetes, hypertension, cancer, cognitive dysfunction, and atherosclerosis.