Synthesis of Enantiopure gamma-Lactones via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of gamma-Keto Acids
Synthesis of Enantiopure gamma-Lactones via a RuPHOX-Ru Catalyzed Asymmetric Hydrogenation of gamma-Keto Acids
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通过 RuPHOX-Ru 催化 γ-酮酸不对称氢化合成对映体纯 γ-内酯
DOI：
10.1002/adsc.201801186
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发表时间：
2019
影响因子：
5.4
通讯作者：
Zhang Wanbin
中科院分区：
文献类型：
--
作者：
Li Jing;Ma Yujie;Lu Yufei;Liu Yangang;Liu Delong;Zhang Wanbin
已开发了RuPHOX−Ru催化的γ-酮酸不对称氢化，以高产率和高达97% ee提供相应的对映体纯γ-内酯。 该反应可以在指定的反应条件下以相对低的催化剂负载（高达10000 S/C）以克规模进行，并且所得产物可以转化为几种对映体纯的结构单元、生物活性化合物和对映体纯的药物。
A RuPHOX−Ru catalyzed asymmetric hydrogenation of γ‐keto acids has been developed, affording the corresponding enantiopure γ‐lactones in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 10000 S/C) under the indicated reaction conditions and the resulting products can be transformed to several enantiopure building blocks, biologically active compounds and enantiopure drugs.