Metabolomics revealed decreased level of omega-3 PUFA-derived protective eicosanoids in pregnant women with pre-eclampsia
Metabolomics revealed decreased level of omega-3 PUFA-derived protective eicosanoids in pregnant women with pre-eclampsia
复制标题
代谢组学显示先兆子痫孕妇中 omega-3 PUFA 衍生的保护性类二十烷酸水平降低
DOI：
10.1111/1440-1681.13095
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发表时间：
2019-08-01
影响因子：
2.9
通讯作者：
Zhang, Xu
中科院分区：
文献类型：
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作者：
Liu, Yantao;Zu, Lingjie;Zhang, Xu
先兆子痫（PE）被认为是全球孕妇死亡和发病的主要原因。多不饱和脂肪酸（PUFAs）衍生的类花生酸可能在PE的发生发展中起重要作用。Omega-3 PUFA是孕妇常用的营养补充剂，可以降低血压。然而，PE女性中源自omega-3 PUFA的类花生酸水平尚不清楚。本研究的目的是研究PE的类花生酸代谢特征。我们使用PE孕妇（n = 10）和血压正常孕妇（n = 10）的数据进行了病例对照研究。我们通过基于LC-MS/MS的代谢组学研究了组间类花生酸谱的差异。PE患者血浆中花生四烯酸代谢产物及部分脂氧合酶代谢产物二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）水平呈上升趋势，细胞色素P450代谢产物EPA和DHA水平呈下降趋势。白三烯B4、14，15-二羟基二十碳四烯酸、16-羟基二十二碳六烯酸和8，9-环氧二十碳四烯酸水平与PE发生显著相关。这些类花生酸可能参与了孕妇PE的进展。
Pre-eclampsia (PE) is considered a leading cause of mortality and morbidity in pregnant women worldwide. Eicosanoids derived from polyunsaturated fatty acids (PUFAs) might play an important role in the occurrence and development of PE. Omega-3 PUFAs are nutrients that are popular supplements for pregnant women and can reduce blood pressure. However, the levels of eicosanoids derived from omega-3 PUFAs in women with PE is not clear. The purpose of this study was to investigate the eicosanoid metabolic signature of PE. We performed a case-control study using data for pregnant women (n = 10) with PE and normotensive pregnant women (n = 10). We investigated the difference in eicosanoid profile between the groups by LC-MS/MS-based metabolomics. The plasma levels of arachidonic acid metabolites and some of the lipoxygenase metabolites of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) showed an increasing trend, and those of the cytochrome P450 metabolites of EPA and DHA were decreased in women with PE. Levels of leukotriene B4, 14,15-dihydroxy-eicosatetraenoate, 16-hydroxydocosahexaenoic acid and 8,9-epoxy eicosatetraenoic acid were significantly correlated with PE occurrence. These eicosanoids might take part in the progression of PE in pregnant women.