LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215
LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215
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LncRNA-CDC6 促进乳腺癌进展，并作为 ceRNA 通过海绵 microRNA-215 来靶向 CDC6。
DOI：
10.1002/jcp.27587
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发表时间：
2019-06-01
影响因子：
5.6
通讯作者：
Yang, Qifeng
中科院分区：
文献类型：
--
作者：
Kong, Xiaoli;Duan, Yi;Yang, Qifeng
乳腺癌的快速增殖和转移导致临床预后不良。最近的研究证明，长非编码RNA(LncRNAs)参与了肿瘤的发展。本研究旨在探讨cncRNA-细胞分裂周期6(CDC6)在调控乳腺癌增殖和转移中的作用和机制。临床上，lncRNA-CDC6在肿瘤组织中高表达，并与乳腺癌的临床分期呈正相关。在功能上，异位表达的lncRNA-CDC6通过调节G1期检查点促进细胞增殖，进而促进细胞迁移能力。此外，lncRNA-CDC6还可以通过直接海绵作用于microRNA-215(miR-215)而发挥竞争内源RNA(CerNA)的作用，从而进一步调节CDC6的表达。综上所述，我们的研究结果证明，lncRNA-CDC6可以作为CERNA发挥作用，促进乳腺癌细胞的增殖和转移，为临床上判断乳腺癌的预后提供了一种新的指标。
Rapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA-cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast cancer. Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. Functionally, the ectopic expression of lncRNA-CDC6 promoted proliferation via regulation of G1 phase checkpoint, and further promoting the migration capability. Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which further regulating the expression of CDC6. Taken together, our results proved that lncRNA-CDC6 could function as ceRNA and promote the proliferation and metastasis of breast cancer cells, which provided a novel prognostic marker for breast cancers in clinic.