Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography.
Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography.
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DOI：
10.1001/archpsyc.1987.01800140028004
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发表时间：
1987-02
影响因子：
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通讯作者：
R. Gur;S. Resnick;R. Gur;A. Alavi;S. Caroff;M. Kushner;M. Reivich
中科院分区：
文献类型：
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作者：
R. Gur;S. Resnick;R. Gur;A. Alavi;S. Caroff;M. Kushner;M. Reivich
使用正电子发射断层扫描（PET）和18-F-氟脱氧葡萄糖，对15名精神分裂症患者和8名对照者的大脑葡萄糖代谢进行了两次测量。研究间隔3至33周。在第一项研究中，患者未接受药物治疗，而在第二项研究中，大多数患者接受了精神抑制剂治疗。从研究1到研究2，平均全脑代谢率、区域皮质活动或皮质下到皮质活动的梯度没有变化。在第一项研究中，精神分裂症患者的皮层下到皮层梯度更陡，这在第二项研究中仍然存在。该梯度的变化与临床状态的变化无关。偏侧性（右-左）在所有研究中是稳定的，相对于左半球代谢，右半球代谢水平更高的变化与临床改善相关。这些结果支持了精神分裂症患者大脑半球活动异常的假设，并暗示皮质下-皮质梯度是另一个值得进一步探索的维度。
Cerebral glucose metabolism was measured twice in a sample of 15 schizophrenics and eight controls, using positron emission tomography (PET) with 18-F-fluorodeoxyglucose. Studies were separated by three to 33 weeks. Patients were unmedicated during the first study, and the majority were receiving neuroleptics during the second study. There were no changes from study 1 to study 2 in average whole-brain metabolic rates, regional cortical activity, or the gradient of subcortical to cortical activity. The steeper subcortical to cortical gradient in schizophrenics, present in the first study, persisted in the second. Changes in this gradient were uncorrelated with changes in clinical status. Laterality (right-left) was stable across studies, and changes toward higher right relative to left hemispheric metabolism were correlated with clinical improvement. The results support the hypothesis of abnormal hemispheric activity in schizophrenia and implicate the subcortical-cortical gradient as another dimension that merits further exploration.