Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa
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DOI：
10.1016/j.bmc.2006.09.024
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发表时间：
2007-02-01
影响因子：
3.5
通讯作者：
Yoshikawa, Masayuki
中科院分区：
文献类型：
--
作者：
Matsuda, Hisashi;Yoshida, Kazutoshi;Yoshikawa, Masayuki
Principal rotenoids (deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3-30 mu M) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of isoflavones and several flavans as well as rotenoids showed moderate or substantial anti -proliferative activities. (c) 2006 Elsevier Ltd. All rights reserved.
