A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women.
A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women.
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DOI：
10.1155/2016/3204083
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发表时间：
2016
影响因子：
2.8
通讯作者：
Tonacchera M
中科院分区：
文献类型：
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作者：
Benelli E;Del Ghianda S;Di Cosmo C;Tonacchera M
导论.我们评估了肌醇（MI）和D-手性肌醇（DCI）联合治疗受多囊卵巢综合征（PCOS）影响的年轻超重女性的效果，PCOS的特征是少排卵或无排卵和高雄激素血症，与胰岛素抵抗相关。方法.我们招募了46名PCOS患者，并将他们随机分为两组，A组和B组，分别以40：1的比例接受MI + DCI联合治疗或安慰剂（叶酸）治疗6个月。因此，我们分析了治疗前和治疗后FSH、LH、17-β-雌二醇、性激素结合球蛋白、雄烯二酮、游离睾酮、硫酸脱氢表雄酮、HOMA指数、空腹血糖和胰岛素。结果仅在MI + DCI联合治疗组中，我们记录到LH、游离睾酮、空腹胰岛素和HOMA指数的统计学显著性降低;在相同患者中，我们观察到17-β-雌二醇水平的统计学显著性升高。结论. MI加DCI联合治疗可有效改善年轻肥胖PCOS患者的内分泌代谢指标。
Introduction. We evaluated the effects of a therapy that combines myo-inositol (MI) and D-chiro-inositol (DCI) in young overweight women affected by polycystic ovary syndrome (PCOS), characterized by oligo- or anovulation and hyperandrogenism, correlated to insulin resistance. Methods. We enrolled 46 patients affected by PCOS and, randomly, we assigned them to two groups, A and B, treated, respectively, with the association of MI plus DCI, in a 40 : 1 ratio, or with placebo (folic acid) for six months. Thus, we analyzed pretreatment and posttreatment FSH, LH, 17-beta-Estradiol, Sex Hormone Binding Globulin, androstenedione, free testosterone, dehydroepiandrosterone sulphate, HOMA index, and fasting glucose and insulin. Results. We recorded a statistically significant reduction of LH, free testosterone, fasting insulin, and HOMA index only in the group treated with the combined therapy of MI plus DCI; in the same patients, we observed a statistically significant increase of 17-beta-Estradiol levels. Conclusions. The combined therapy of MI plus DCI is effective in improving endocrine and metabolic parameters in young obese PCOS affected women.