Inflammation and Liver Cancer New Molecular Links
Inflammation and Liver Cancer New Molecular Links
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DOI：
10.1111/j.1749-6632.2009.03704.x
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发表时间：
2009-01-01
期刊：
影响因子：
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通讯作者：
Avila, M. A.
中科院分区：
文献类型：
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作者：
Berasain, C.;Castillo, J.;Avila, M. A.
炎症和癌症之间的联系一直被怀疑。流行病学研究已经确定，许多肿瘤的发生与慢性感染性疾病有关，并且还已知，在没有感染的情况下持续的炎症增加了癌症的风险并加速了癌症的发展。炎症相关癌症的一个明显例子是肝细胞癌（HCC）。HCC是一种在慢性炎症背景下缓慢发展的肿瘤，主要由暴露于感染因子（嗜肝病毒）或毒性化合物（乙醇）引发。连接炎症和癌症的分子联系尚不完全清楚，但过去几年收集的证据开始定义确切的机制。在这篇文章中，我们回顾了最令人信服的证据的作用，转录因子，如NF-κ B B和STAT 3，细胞因子，如IL-6和IL-1 α，配体的EGF受体和其他炎症介质在癌症的发展，特别是在肝癌。对炎症反应和肿瘤形成之间的联系进行分子解剖，将为更好地治疗癌症铺平道路。
A connection between inflammation and cancer has been long suspected. Epidemiological studies have established that many tumors occur in association with chronic infectious diseases, and it is also known that persistent inflammation in the absence of infections increases the risk and accelerates the development of cancer. One clear example of inflammation-related cancer is hepatocellular carcinoma (HCC). HCC is a type tumor that slowly unfolds on a background of chronic inflammation mainly triggered by exposure to infectious agents (hepatotropic viruses) or to toxic compounds (ethanol). The molecular links that connect inflammation and cancer are not completely known, but evidences gathered over the past few years are beginning to define the precise mechanisms. In this article we review the most compelling evidences on the role of transcription factors such as NF-kappa B and STAT3, cytokines like IL-6 and IL-1 alpha, ligands of the EGF receptor and other inflammatory mediators in cancer development, with special emphasis in HCC. The molecular dissection of the pathways connecting the inflammatory reaction and neoplasia will pave the way for better therapies to treat cancers.