Endocrine Assessment of Prepubertal Boys With a History of Cryptorchidism and/or Hypospadias: A Pilot Study
Endocrine Assessment of Prepubertal Boys With a History of Cryptorchidism and/or Hypospadias: A Pilot Study
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DOI：
10.1016/j.juro.2011.01.018
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发表时间：
2011-06-01
影响因子：
6.6
通讯作者：
Hayashi, Yutaro
中科院分区：
文献类型：
--
作者：
Iwatsuki, Shoichiro;Kojima, Yoshiyuki;Hayashi, Yutaro
目的：精液质量差、睾丸癌、隐睾症和尿道下裂四种疾病被认为是睾丸发育不全综合征的代表，并被认为有共同的病因。我们通过测定血清激素水平来预测有隐睾史和/或尿道下裂病史的青春期前男孩的睾丸功能。材料和方法：82名青春期前男孩在儿童时期接受了睾丸固定术和/或尿道下裂修复术。手术治疗包括隐睾症(组1 23例)、尿道下裂(组2 49例)、隐睾症和尿道下裂(组3 10例)、睾丸鞘膜积液(对照组4 7例)。分别按年龄<12.5岁、12.5~13.5岁、>13.5岁和Tanner青春期测定血清黄体生成素、卵泡刺激素和总睾酮。结果：在12.5~13.5岁和>13.5岁，Tanner分期2和3，组3的促卵泡激素水平显著高于组1、2和4(p<；0.05)。然而，促黄体激素和睾酮在不同年龄或晒黑阶段的人群中没有差异。结论：隐睾症合并尿道下裂患者的睾丸功能受损程度明显高于隐睾症或尿道下裂患者，临床支持睾丸发育不全综合征的共同起源假说。
Purpose: Four disorders, including poor semen quality, testicular cancer, cryptorchidism and hypospadias, are thought to represent testicular dysgenesis syndrome and have been hypothesized to share a common etiology. We predicted testicular function in prepubertal boys with a history of cryptorchidism and/or hypospadias by measuring serum hormone levels.Materials and Methods: A total of 82 prepubertal boys who underwent orchiopexy and/or hypospadias repair in childhood were enrolled in the study. Patients were surgically treated for cryptorchidism (23 in group 1), hypospadias (49 in group 2), cryptorchidism and hypospadias (10 in group 3), and hydrocele testis (7 in control group 4). Serum hormones, including luteinizing hormone, follicle-stimulating hormone and total testosterone, were measured separately by age less than 12.5, 12.5 to 13.5 and greater than 13.5 years, and by Tanner pubertal stage.Results: Follicle-stimulating hormone in group 3 was significantly higher than in groups 1, 2 and 4 at ages 12.5 to 13.5 and greater than 13.5 years, and for Tanner stages 2 and 3 (p < 0.05). However, luteinizing hormone and testosterone did not differ among the groups regardless of age or Tanner stage. Group 3 patients had significantly higher follicle-stimulating hormone regardless of the severity of cryptorchidism or hypospadias.Conclusions: Data suggest that testicular function in patients with cryptorchidism plus hypospadias is more severely impaired than that in patients with cryptorchidism or hypospadias, lending clinical support to the testicular dysgenesis syndrome hypothesis of a common origin.