Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV
Increased frontal white matter diffusion is associated with glial metabolites and psychomotor slowing in HIV
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DOI：
10.1016/j.jneuroim.2004.08.043
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发表时间：
2004-12-01
影响因子：
3.3
通讯作者：
Ernst, T
中科院分区：
文献类型：
--
作者：
Cloak, CC;Chang, L;Ernst, T
弥散加权成像（DWI）测量对显微镜脑损伤敏感的脑水扩散。共11例HIV血清阳性患者进行了比较，14例血清阴性的主题使用DWI，质子磁共振波谱（H-1 MRS），神经心理测试。HIV患者的表观扩散系数（ADC）显著增加，主要是在额叶白色物质（FWM;+5%，p=0.01）。扩散率与神经胶质标记物肌醇正相关（r=0.5，p=0.008），与认知能力负相关（NPZ-8综合评分; r=-0.43，p=0.05）。这些发现表明，脑水扩散增加可能反映了神经胶质细胞活化或炎症增加，这反过来可能导致艾滋病毒患者的认知缺陷。(C)2004 Elsevier B. V.保留所有权利。
Diffusion-weighted imaging (DWI) measures brain water diffusion that is sensitive to microscopic brain injury. A total of 11 HIV seropositive patients were compared to 14 seronegative subjects using DWI, proton magnetic resonance spectroscopy (H-1 MRS), and neuropsychological tests. The apparent diffusion coefficient (ADC) was significantly increased in the HIV patients, primarily in the frontal white matter (FWM; +5%, p=0.01). Diffusivity correlated positively with the glial marker myo-inositol (r=0.5, p=0.008) and negatively with cognitive performance (NPZ-8 composite score; r=-0.43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients. (C) 2004 Elsevier B.V. All rights reserved.