Ozone and hypertensive disorders of pregnancy in Florida: Identifying critical windows of exposure.
Ozone and hypertensive disorders of pregnancy in Florida: Identifying critical windows of exposure.
复制标题
佛罗里达州怀孕的臭氧和高血压疾病：确定暴露的关键窗户。
DOI：
10.1016/j.envres.2016.12.002
复制
发表时间：
2017-02
影响因子：
8.3
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Hu H;Ha S;Xu X
臭氧（O3）与妊娠高血压疾病（HDP）有关。然而，报告的结果不一致，没有研究检查了怀孕期间的关键暴露窗口。我们使用佛罗里达出生人口动态统计记录，调查2005年至2007年期间655，529例妊娠中HDP和O3暴露之间的关系。使用分层贝叶斯时空统计模型在分娩时在母亲的家庭地址评估个人O3暴露。我们在三个预定义的暴露窗口（包括妊娠1、妊娠2和妊娠1和2）以及前两个妊娠期的每周使用分布滞后模型检查了相关性。HDP孕妇的平均O3暴露量（第1个月39.07，第2个月39.02，第1和第2个月39.06，单位：ppb）高于无HDP孕妇（第1个月38.65，第2个月38.57，第1和第2个月38.61，单位：ppb）。在校正的logistic回归模型中，O3每增加5 ppb，观察到HDP的几率增加（ORTrimester 1 =1.04，95% CI：1.03，1.06; ORTrimester 2 =1.03，95% CI：1.02，1.04; ORTrimester1&2=1.07，95% CI：1.05，1.08）。在分布滞后模型中，随着妊娠第1至24周期间O3暴露量的增加，观察到HDP的几率升高，妊娠早期的几率更高。怀孕期间的O3暴露与HDP的几率增加有关，怀孕早期似乎是一个潜在的关键暴露窗口。
Ozone (O3) has been linked to hypertensive disorders of pregnancy (HDP). However, inconsistent results have been reported, and no study has examined the critical exposure windows during pregnancy. We used Florida birth vital statistics records to investigate the association between HDP and O3 exposure among 655,529 pregnancies with conception dates between 2005 and 2007. Individual O3 exposure was assessed at mothers’ home address at the time of delivery using the Hierarchical Bayesian space-time statistical model. We examined the association during three predefined exposure windows including trimester 1, trimester 2, and trimesters 1&2, as well as in each week of the first two trimesters using distributed lag models. Pregnancies with HDP had a higher mean exposure to O3 (39.07 in trimester 1, 39.02 in trimester 2, and 39.06 in trimesters 1&2, unit: ppb) than those without HDP (38.65 in trimester 1, 38.57 in trimester 2, and 38.61 in trimesters 1&2, unit: ppb). In the adjusted logistic regression model, increased odds of HDP were observed for each 5 ppb increase in O3 (ORTrimester1=1.04, 95% CI: 1.03, 1.06; ORTrimester2=1.03, 95% CI: 1.02, 1.04; ORTrimester1&2=1.07, 95% CI: 1.05, 1.08). In the distributed lag models, elevated odds of HDP were observed with increased O3 exposure during the 1st to 24th weeks of gestation, with higher odds during early pregnancy. O3 exposure during pregnancy is related to increased odds of HDP, and early pregnancy appears to be a potentially critical window of exposure.