Hirsutella sinensis Inhibits Lewis Lung Cancer via Tumor Microenvironment Effector T Cells in Mice
Hirsutella sinensis Inhibits Lewis Lung Cancer via Tumor Microenvironment Effector T Cells in Mice
复制标题
中华被毛孢通过小鼠肿瘤微环境效应 T 细胞抑制 Lewis 肺癌
DOI：
10.1142/s0192415x18500489
复制
发表时间：
2018-01-01
影响因子：
5.7
通讯作者：
Shou, Qiyang
中科院分区：
文献类型：
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作者：
Fu, Huiying;Jin, Lu;Shou, Qiyang
中国被毛孢真菌（HSF）是一种人工替代著名的药物冬虫夏草在人类具有类似的有益效果。我们以前发现HSF可以调节免疫功能和抑制肿瘤生长;然而，这些作用所涉及的机制仍不清楚。因此，在本研究中，我们研究了HSF对小鼠肿瘤微环境中免疫细胞亚群的影响。结果显示，HSF抑制刘易斯肺癌生长，减轻血常规异常，并增强肿瘤浸润T细胞，特别是效应性CD 8（+）T细胞的比例。此外，HSF还改善了免疫抑制微环境，降低了调节性T细胞和髓源性抑制细胞群的比例。为了证实HSF促进效应CD 8（+）T细胞产生的作用，我们进一步评估了HSF治疗后术后转移的变化。事实上，原位肺转移被显著抑制，并且在HSF处理的小鼠中存活时间增加。综上所述，我们的研究结果表明，HSF抑制刘易斯肺癌通过增加有效的CD 8（+）T细胞的人口。
Hirsutella sinensis fungus (HSF) is an artificial substitute of the well-known medicine Cordyceps sinensis with similar beneficial effects in humans. We previously found that HSF can regulate immune function and inhibit tumor growth; however, the mechanisms involved in these effects were still unclear. Accordingly, in this study, we investigated the effects of HSF on immune cell subsets in the tumor microenvironment in mice. The results showed that HSF inhibited Lewis lung cancer growth, alleviated abnormalities in routine blood tests, and enhanced tumor-infiltrating T cells, particularly the proportion of effector CD8(+) T cells. In addition, HSF also ameliorated the immune-suppressive microenvironment and decreased the proportions of regulatory T cell and myeloid-derived suppressor cell populations. To confirm the effects of HSF on promotion of effector CD8(+) T-cell production, we further evaluated changes in postoperative metastasis following treatment with HSF. Indeed, orthotopic lung metastasis was significantly suppressed, and survival times were increased in HSF-treated mice. Taken together, our findings suggested that HSF inhibited Lewis lung cancer by enhancing the population of effective CD8(+) T cells.