A novel withanolide with an unprecedented carbon skeleton from Physalis angulata.
A novel withanolide with an unprecedented carbon skeleton from Physalis angulata.
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DOI：
10.1039/c6ob02656g
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发表时间：
2017-02
影响因子：
3.2
通讯作者：
Cheng-Peng Sun;A. Kutateladze;Feng Zhao;Lixia Chen;F. Qiu
中科院分区：
文献类型：
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作者：
Cheng-Peng Sun;A. Kutateladze;Feng Zhao;Lixia Chen;F. Qiu
从酸浆（PhysalisangulataL.）的茎和叶中分离得到一个新化合物，即芳香酸浆素A（aromaphysalinA，1），它具有一个特殊的C（11）-C（15）键和一个前所未有的4，9-环化芳香环（A环）。其结构通过HRESIMS、2D NMR谱和理论计算的组合确定。化合物1对NO的产生具有抑制活性，IC 50值为51.64 μM。一个合理的生物合成途径1进行了讨论。
A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)-C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 μM. A plausible biosynthetic pathway for 1 is also discussed.