Anogenital distance measured at weaning is correlated with measures of blood chemistry and behaviors in 450-day-old female mice.
Anogenital distance measured at weaning is correlated with measures of blood chemistry and behaviors in 450-day-old female mice.
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断奶时测量的肛门生殖器距离与 450 日龄雌性小鼠的血液化学和行为测量相关。
DOI：
10.1016/s0031-9384(03)00054-4
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发表时间：
2003
影响因子：
2.9
通讯作者：
Vandenbergh,DavidJ
中科院分区：
文献类型：
--
作者：
Kerin,TaraK;Vogler,GeorgeP;Blizard,DavidA;Stout,JosephT;McClearn,GeraldE;Vandenbergh,DavidJ
在雌性小鼠中，断奶时测量的肛门生殖距离(AGD)提供了从两侧的雄性小鼠产仔子宫暴露于睾酮的估计。在C57BL/6J×DBA2/J杂交F2雌性小鼠断奶时，测量了肛门发育距离指数(AGDI)的一个变量，该变量使用了体重回归后的AGD残差值(AGDWTRES)。用AGDWTRES检测450日龄母猪宫内环境与血液生化指标及活动相关行为的关系。较长的AGDWTRES值与较低的钙、胆固醇、磷、铁和蛋白质水平相关，这与预期方向相反，这是基于血液化学的潜在性别差异。发现AGDWTRES与两个与活动相关的指标(探索测试中的后轮数量和鼠标输入的杆子扇区数量)之间存在正相关。这些发现表明，根据AGDWTRES的指标，子宫内与雄性动物的接近可能会对血液化学和行为的基本方面产生影响，这些影响一直延续到小鼠的中年，并可能在健康方面发挥重要作用。
In female mice, anogenital distance (AGD), measured at weaning, provides an estimate of uterine exposure to testosterone from flanking male mouse littermates. A variant of the anogenital distance index (AGDI) that uses the residual value of AGD after accounting for the effect of weight by regression (AGDWTRES) was measured at weaning in F2female mice from a C57BL/6J×DBA2/J cross. AGDWTRES was used to examine the relationship between intrauterine environment and blood chemistry variables and activity-related behaviors when the females were 450 days old. Longer AGDWTRES values correlated with lower levels of calcium, cholesterol, phosphorus, iron, and protein, which is opposite to the expected direction, based on underlying sex differences for blood chemistry. A positive correlation was found between AGDWTRES and two activity-related measures (the number of rears in a test of exploration, and the number of sectors of a rod that are entered by the mouse). These findings suggest that in utero proximity to males, as indexed by AGDWTRES, may have effects on fundamental aspects of blood chemistry and behavior that extend well into mouse middle age, and could play an important role in health.