Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males
Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males
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DOI：
10.1016/j.molbrainres.2005.07.008
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发表时间：
2005-10-31
期刊：
影响因子：
--
通讯作者：
Tsai, SJ
中科院分区：
文献类型：
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作者：
Cheng, CY;Hong, CJ;Tsai, SJ
来自动物研究以及人类基因扫描的数据表明，脑源性神经营养因子（BDNF）作为神经营养因子家族的一员，可能参与了药物滥用的潜在机制。本研究验证了BDNF基因Val66Met多态性与药物滥用相关的假设。我们在103例甲基苯丙胺依赖者、200例海洛因依赖者以及122例正常对照者中研究了这种多态性。我们还考虑了这种多态性与海洛因依赖者药物滥用发病年龄的关联。在甲基苯丙胺依赖者（P = 0.046）或海洛因依赖者（P = 0.045）与对照组之间，发现BDNF Val66Met基因型分布存在显著差异，这表明较低的66Met携带者频率与药物滥用有关。此外，在海洛因依赖组中，与Met等位基因携带者相比，Val/Val纯合子药物滥用发病较晚。研究结果表明，BDNF Val66Met多态性或附近的基因座可能参与了药物滥用的发病机制。我们的发现支持了先前的基因扫描结果，即BDNF可能导致药物滥用易感性。（c）2005爱思唯尔B.V.版权所有。
Data from animal studies and from genetic scans in humans suggest that brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, may be involved in the mechanisms underlying substance abuse. The present study tested the hypothesis that the BDNF-gene Val66Met polymorphism is associated with substance abuse. We studied this polymorphism in 103 methamphetamine- and 200 heroin-dependent cases and 122 normal controls. We also considered the association of this polymorphism with age of onset of substance abuse in the hero in-dependent cases. Significant differences in BDNF Val66Met genotype distribution were found between subjects dependent on methamphetamine (P = 0.046) or heroin (P = 0.045) and controls, suggesting that the lower 66Met carrier frequency is associated with substance abuse. Furthermore, in the heroin-dependent group, the Val/Val homozygotes had a later onset of substance abuse compared with the Met allele carriers. The results suggest that the BDNF Val66Met polymorphism or a nearby locus may be involved in the pathogenesis of substance abuse. Our findings support previous genetic scan results showing that BDNF may contribute to substance abuse vulnerability. (c) 2005 Elsevier B.V. All rights reserved.