Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil.
Validation of a hierarchical deterministic record-linkage algorithm using data from 2 different cohorts of human immunodeficiency virus-infected persons and mortality databases in Brazil.
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DOI：
10.1093/aje/kwn249
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发表时间：
2008-12-01
影响因子：
5
通讯作者：
Harrison LH
中科院分区：
文献类型：
--
作者：
Pacheco AG;Saraceni V;Tuboi SH;Moulton LH;Chaisson RE;Cavalcante SC;Durovni B;Faulhaber JC;Golub JE;King B;Schechter M;Harrison LH
失访是人类免疫缺陷病毒（HIV）患者队列中偏差的一个主要来源，并可能导致死亡率的低估。作者开发了一种分层确定性链接算法，主要用于艾滋病毒感染者群体，以恢复失访患者的生命状态信息。巴西里约热内卢 2 个队列中已知死亡患者的数据以及里约热内卢州 1999-2006 年死亡率数据库的数据用于验证该算法。在不遗漏任何信息的情况下，全自动程序的灵敏度为 92.9%，特异性为 100%。当自动化程序与文书审查相结合时，在死亡率为 5%、母亲姓名缺失 20% 的情况下，敏感性达到 96.5%，特异性达到 100%。在实际应用中，该算法显着增加了队列中的死亡率并降低了失访率。 23.9% 的匹配记录并未将 HIV 或获得性免疫缺陷综合症作为死因，这一发现强化了搜索全因死亡率数据库的必要性，并提醒人们可能低估了死亡率。这些结果表明，该算法足够准确，可以恢复队列研究中失访患者的生命状态信息。
Loss to follow-up is a major source of bias in cohorts of patients with human immunodeficiency virus (HIV) and could lead to underestimation of mortality. The authors developed a hierarchical deterministic linkage algorithm to be used primarily with cohorts of HIV-infected persons to recover vital status information for patients lost to follow-up. Data from patients known to be deceased in 2 cohorts in Rio de Janeiro, Brazil, and data from the Rio de Janeiro State mortality database for 1999–2006 were used to validate the algorithm. A fully automated procedure yielded a sensitivity of 92.9% and specificity of 100% when no information was missing. When the automated procedure was combined with clerical review, in a scenario of 5% death prevalence and 20% missing mothers’ names, sensitivity reached 96.5% and specificity 100%. In a practical application, the algorithm significantly increased death rates and decreased the rate of loss to follow-up in the cohorts. The finding that 23.9% of matched records did not give HIV or acquired immunodeficiency syndrome as the cause of death reinforces the need to search all-cause mortality databases and alerts for possible underestimation of death rates. These results indicate that the algorithm is accurate enough to recover vital status information on patients lost to follow-up in cohort studies.
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影响因子：
56.9
作者：
NEWCOMBE, HB;KENNEDY, JM;JAMES, AP
通讯作者：
JAMES, AP
影响因子：
2
作者：
Gomatam, S;Carter, R;Mitchell, G
通讯作者：
Mitchell, G
影响因子：
120.7
作者：
Frisch, M;Biggar, RJ;Goedert, JJ
通讯作者：
Goedert, JJ
影响因子：
168.9
作者：
Braitstein, P;Brinkhof, MWG;Egger, M
通讯作者：
Egger, M
DOI：
10.1080/14639230400005974
发表时间：
2004-09-01
期刊：
MEDICAL INFORMATICS AND THE INTERNET IN MEDICINE
影响因子：
--
作者：
Quantin, C;Binquet, C;Allaert, FA
通讯作者：
Allaert, FA