Antioxidant gene expression in active and sedentary house mice (Mus domesticus) selected for high voluntary wheel-running behavior.
Antioxidant gene expression in active and sedentary house mice (Mus domesticus) selected for high voluntary wheel-running behavior.
复制标题
选择具有高度自愿轮跑行为的活跃和久坐家鼠（Mus Domesticus）的抗氧化基因表达。
DOI：
10.1093/genetics/161.4.1763
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发表时间：
2002
期刊：
影响因子：
3.3
通讯作者：
Carter,PatrickA
中科院分区：
文献类型：
--
作者：
Bronikowski,AnneM;Morgan,TheodoreJ;GarlandJr,Theodore;Carter,PatrickA
We present liver mRNA levels of the two antioxidant enzymes catalase (CAT) and Mn-superoxide dismutase (SOD2) in four treatment groups of house mice assayed by RNase protection at 20 months of age. These groups were mice from four replicate selection and four replicate control lines from the sixteenth generation of selective breeding for high voluntary wheel running, housed with or without running wheels from age 3 weeks through 20 months. Exercising control females had induced CAT expression; SOD2 exhibited a similar pattern in females from two of the four control lines. Exercising male mice had induced CAT expression, but not SOD2 expression, irrespective of genetic background. We discuss these results with respect to both evolutionary (genetic) and training (exercise-induced) adaptations and explore predictions of these results in relation to the oxidative-damage theory of senescence.
