Pattern of FDG and MET Distribution in High- and Low-Grade Gliomas on PET Images.
Pattern of FDG and MET Distribution in High- and Low-Grade Gliomas on PET Images.
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PET 图像上高级别和低级别胶质瘤的 FDG 和 MET 分布模式。
DOI：
10.1097/rlu.0000000000002460
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发表时间：
2019
影响因子：
10.6
通讯作者：
Momose T.
中科院分区：
文献类型：
--
作者：
Takahashi M;Soma T;Mukasa A;Tanaka S;Yanagisawa S;Momose T.
材料与方法回顾性分析行FDG-PET和MET-PET检查以及手术治疗的患者。所有肿瘤均经组织学诊断，其中高级别胶质瘤44例，低级别胶质瘤19例。肿瘤与正常（T/N）比值和肿瘤本身的最大值的代谢指标之间的高和低级别肿瘤进行了比较。结果T/N（肿瘤值除以正常皮质值）是区分高级别和低级别胶质瘤的最有效方法（FDG-PET的曲线下面积为0.800; MET-PET的曲线下面积为0.773）。潜在浸润体积有效区分了高级别和低级别胶质瘤（43.8±30.2 mL vs 14.0±12.6 mL; P= 0.005 [t检验]）。FDG-PET上的T/N（截止值为0.9或更高）和MET-PET上的T/N（截止值为3.0或更高）以及潜在浸润体积（截止值为20.0 mL或更高）的组合在区分高级别和低级别胶质瘤方面提供了89%的诊断准确性。可能有助于区分高级别和低级别胶质瘤。
Materials and MethodsPatients who underwent both FDG-PET and MET-PET, as well as surgical treatment, were retrospectively identified. All tumors were diagnosed histologically and included 44 high-grade and 19 low-grade gliomas. Metabolic indices of tumor-to-normal (T/N) ratio and maximum value within the tumor itself were compared between high-and low-grade tumors. A calculation method for potential infiltrative tumor volume was developed and compared between these 2 grades.ResultsT/N, calculated as tumor value divided by normal cortex value, was the most effective (area under the curve, 0.800 for FDG-PET; area under the curve, 0.773 for MET-PET) for differentiating high-and low-grade gliomas. Potential infiltrative volume effectively distinguished between high-and low-grade glioma (43.8±30.2 mL vs 14.0±12.6 mL; P= 0.005 [t test]). A combination of T/N, with a cutoff value of 0.9 or higher on FDG-PET and/or 3.0 or higher on MET-PET, and potential infiltrative volume, with a cutoff value of 20.0 mL or higher, provided a diagnostic accuracy of 89% in distinguishing high-from low-grade gliomas.ConclusionsEvaluation of potential infiltrative volume surrounding the tumor core area, in addition to the T/N ratio of the tumor core, may help distinguish between high-and low-grade gliomas.