In-vivo measurement of cortical morphology: means and meanings
In-vivo measurement of cortical morphology: means and meanings
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DOI：
10.1097/wco.0b013e32833a0afc
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发表时间：
2010-08-01
影响因子：
4.8
通讯作者：
Cachia, Arnaud
中科院分区：
文献类型：
--
作者：
Mangin, Jean-Francois;Jouvent, Eric;Cachia, Arnaud
综述目的皮质套厚度变异性的研究现在是神经影像学的一个关键问题。在这里，我们描述了旨在研究皮质折叠形态变异性的最新趋势。最近的发现，计算机化的三维版本的回转指数和其他专用于折叠模式的形态测量特征在精神综合征和神经系统疾病中被修改。这些观察结果为涉及异常发育或异常衰老的机制提供了新的见解。总结折叠形态的量化将有助于全球努力从神经影像数据构建生物标志物，特别关注发育疾病。
Purpose of reviewStudy of the variability of the cortical mantle thickness is now a key issue in neuroimaging. Here we describe a more recent trend aiming at the study of the variability of the cortical folding morphology.Recent findingsComputerized three-dimensional versions of gyrification index and other morphometric features dedicated to the folding patterns are modified in psychiatric syndromes and neurologic disorders. These observations provide new insights into the mechanisms involved in abnormal development or abnormal aging.SummaryQuantification of the folding morphology will contribute to the global endeavor aiming at building biomarkers from neuroimaging data, with a specific focus on developmental diseases.