Effects of obesity on breathing pattern, ventilatory neural drive and mechanics
Effects of obesity on breathing pattern, ventilatory neural drive and mechanics
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DOI：
10.1016/j.resp.2009.06.012
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发表时间：
2009-09-30
影响因子：
2.3
通讯作者：
Ahmaidi, Said
中科院分区：
文献类型：
--
作者：
Chlif, Mehdi;Keochkerian, David;Ahmaidi, Said
本研究的目的是评估肥胖是否会引起呼吸模式和通气神经驱动和力学的改变。对34名男性肥胖受试者（BMI, 39 +/- 6 kg/m(2)）和18名对照组（BMI, 23 +/- 3 kg/m(2)）进行测量，包括人体测量参数、肺活量测定、呼吸方式、口腔闭合压、最大吸气压力和呼吸功。结果显示，与对照组相比，肥胖组肺活量（FEV1% pred, FVC% pred）和最大吸气压力（p -1max）显著降低（p < 0.001）。肥胖组fR/VT比值高于对照组（p < 0.001）。（fR/VF）的增加与平均吸气压力与最大吸气压力之比（p -1/ p -1max）和占空比（T1/T-TOT） (p
The purpose of this study was to assess whether obesity induces changes in breathing pattern and ventilatory neural drive and mechanics. Measurements performed in 34 male obese subjects (BMI, 39 +/- 6 kg/m(2)) and 18 controls (BMI, 23 +/- 3 kg/m(2)) included anthropometric parameters, spirometry, breathing patterns, mouth occlusion pressure, maximal inspiratory pressure and work of breathing. The results show that spirometric flow (FEV1% pred, FVC% pred) and maximal inspiratory pressure (P-1max) were significantly lowers (p < 0.001) in obese subjects compared to controls. The (fR/VT) ratio was higher in obese subjects than in controls (p < 0.001). The increase in (fR/VF) was associated with an increase in the ratio of mean inspiratory pressure to maximal inspiratory pressure (P-1/P-1max) and the duty cycle (T1/T-TOT) (p