Genetic correlates of throat and skin isolates of group A streptococci
Genetic correlates of throat and skin isolates of group A streptococci
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DOI：
10.1093/infdis/173.4.896
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发表时间：
1996-04-01
影响因子：
6.4
通讯作者：
Hollingshead, SK
中科院分区：
文献类型：
--
作者：
Bessen, DE;Sotir, CM;Hollingshead, SK
A组链球菌的咽喉和皮肤菌株的离散群体的存在早已被认识到;然而，这种区别的分子基础尚不清楚。emm基因结构进行了分析105株分离自明确定义的A组链球菌疾病的患者：单纯性咽炎，脓疱，和急性风湿热。四emm基因亚家族的形式，定义的核苷酸序列差异的区域编码的肽聚糖跨域的M和M样表面蛋白，被发现存在于五个不同的染色体模式之间的自然发生的菌株。emm亚家族基因的数量和排列与疾病之间有很强的相关性，这些发现为历史上的“咽喉”、“皮肤”和“风湿性”类型的参考提供了遗传学基础。
The existence of discrete populations of throat and skin strains of group A streptococci has long been recognized; however, a molecular basis for this distinction is not known. The emm gene structure was analyzed for 105 isolates obtained from patients with well-defined group A streptococcal diseases: uncomplicated pharyngitis, impetigo, and acute rheumatic fever. Four emm gene subfamily forms, defined by nucleotide sequence differences in regions encoding the peptidoglycan-spanning domain of M and M-like surface proteins, were found to exist in five different chromosomal patterns among naturally occurring isolates. Strong correlations were made between disease and the number and arrangement of emm subfamily genes, These findings provide a genetic basis for the historical references to ''throat,'' ''skin,'' and ''rheumatogenic'' types.