Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome
Prenatal androgen excess negatively impacts body fat distribution in a nonhuman primate model of polycystic ovary syndrome
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DOI：
10.1038/sj.ijo.0803638
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发表时间：
2007-10-01
影响因子：
4.9
通讯作者：
Abbott, D. H.
中科院分区：
文献类型：
--
作者：
Bruns, C. M.;Baum, S. T.;Abbott, D. H.
前言：孕期雄激素(PA)雌性恒河猴与多囊卵巢综合征(PCOS)雌性恒河猴有共同的代谢异常。妊娠早期暴露(E)导致胰岛素抵抗、胰岛β细胞功能受损和2型糖尿病，而妊娠晚期暴露(L)导致胰岛素敏感性超常，并随着体重指数(BMI)的增加而下降。目的：确定雌性PA是否改变了体内脂肪分布。设计：对5只早期治疗PA(EPA)、5只晚期治疗PA(LPA)和5只对照成年雌性猕猴进行了人体测量、双X射线吸收测量(DXA)和腹部计算机断层扫描(CT)。5名对照组和5名EPA女性接受了静脉葡萄糖耐量试验，以评估身体成分和糖调节的关系。结果：年龄、体重、BMI和人体测量学指标没有差异。LPA女性的DXA测定的总脂肪和体脂百分比以及腹部总脂肪和腹部脂肪百分比比EPA或对照女性高20%(P
Introduction: Prenatally androgenized (PA) female rhesus monkeys share metabolic abnormalities in common with polycystic ovary syndrome (PCOS) women. Early gestation exposure (E) results in insulin resistance, impaired pancreatic beta-cell function and type 2 diabetes, while late gestation exposure (L) results in supranormal insulin sensitivity that declines with increasing body mass index (BMI).Objective: To determine whether PA females have altered body fat distribution.Design: Five early-treated PA (EPA), five late-treated PA (LPA) and five control adult female monkeys underwent somatometrics, dual-X-ray absorptiometry (DXA) and abdominal computed tomography (CT). Five control and five EPA females underwent an intravenous glucose tolerance test to assess the relationship between body composition and glucoregulation.Results: There were no differences in age, weight, BMI or somatometrics. LPA females had similar to 20% greater DXA-determined total fat and percent body fat, as well as total and percent abdominal fat than EPA or control females (P