Is chronic airway obstruction from cotton dust exposure reversible?
Is chronic airway obstruction from cotton dust exposure reversible?
复制标题
接触棉尘导致的慢性气道阻塞可以逆转吗？
DOI：
10.1097/01.ede.0000142141.28139.25
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Christiani,DavidC
中科院分区：
文献类型：
--
作者：
Wang,Xiao-Rong;Zhang,Hong-Xi;Sun,Bi-Xiong;Dai,He-Lian;Pan,Lei-Da;Eisen,EllenA;Wegman,DavidH;Olenchock,StephenA;Christiani,DavidC
Background:Exposure to cotton dust is known to cause chronic airway obstruction, but there is little information on whether the obstructive impairment is reversible after the exposure stops.Methods:Longitudinal changes in lung function were evaluated among 429 cotton textile workers and 449 silk workers in Shanghai, China, beginning in 1981. Both active and retired workers were tested every 4 to 6 years for 15 years.Results:Overall, cotton workers had greater annual declines in forced expiratory volume in 1 second (FEV 1) and forced vital capacity (FVC). Compared with active workers, retired cotton workers had lower annual loss of FEV 1, although the retired workers had a greater loss during their active employment than the currently active workers. No such trends were detected in silk workers. Annual declines in FEV 1 in retired cotton workers were smaller with increasing time since retirement. Multivariate analysis showed that retirement was a substantial contributing factor for improved FEV 1 and FVC in the cotton workers, especially among those who did not smoke. Correspondingly, remission of airflow obstruction, defined as a ratio of FEV 1 and FVC of less than 70%, was more common in retirees than in the active workers, and more common in nonsmokers than in smokers.Conclusion:Chronic airway obstruction related to long-term exposure to cotton dust may be partially reversible after the exposure ceases, although lung function does not return to the level found in unexposed workers.
