Specification of Drosophila hematopoietic lineage by conserved transcription factors
Specification of Drosophila hematopoietic lineage by conserved transcription factors
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DOI：
10.1126/science.288.5463.146
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发表时间：
2000-04-07
期刊：
影响因子：
56.9
通讯作者：
Banerjee, U
中科院分区：
文献类型：
--
作者：
Lebestky, T;Chang, T;Banerjee, U
在果蝇造血系统中观察到的两种主要细胞类型是浆细胞/巨噬细胞和晶体细胞。转录因子Lz（Lozenge）类似于人AML 1（急性髓性白血病-1）蛋白，是胚胎和幼虫造血期间晶体细胞发育所必需的。另一种转录因子Gcm（神经胶质细胞缺失）先前已被证明是浆细胞发育所需的。Gcm的错误表达导致晶体细胞转化为浆细胞。果蝇加塔蛋白Srp（Serpent）是Lz和Gcm表达所必需的，并且是两类血细胞发育所必需的，而Lz和Gcm是以谱系特异性方式所必需的。鉴于Srp和Lz与哺乳动物加塔和AML 1蛋白的相似性，在果蝇中的观察可能对理解哺乳动物造血和白血病具有广泛的意义。
Two major classes of cells observed within the Drosophila hematopoietic repertoire are plasmatocytes/macrophages and crystal cells. The transcription factor Lz (Lozenge), which resembles human AML1 (acute myeloid leukemia-1) protein, is necessary for the development of crystal cells during embryonic and larval hematopoiesis. Another transcription factor, Gcm (glial cells missing), has previously been shown to be required for plasmatocyte development. Misexpression of Gcm causes crystal cells to be transformed into plasmatocytes. The Drosophila GATA protein Srp (Serpent) is required for both Lz and Gcm expression and is necessary for the development of both classes of hemocytes, whereas Lz and Gcm are required in a lineage-specific manner. Given the similarities of Srp and Lz to; mammalian GATA and AML1 proteins, observations in Drosophila are Likely to have broad implications for understanding mammalian hematopoiesis and leukemias.