Dual-Functional Dextran-PEG Hydrogel as an Antimicrobial Biomedical Material
Dual-Functional Dextran-PEG Hydrogel as an Antimicrobial Biomedical Material
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DOI：
10.1002/mabi.201700325
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发表时间：
2018-02-01
影响因子：
4.6
通讯作者：
Xu, Xiaoyang
中科院分区：
文献类型：
--
作者：
Wang, Lei;Li, Xin;Xu, Xiaoyang
微生物感染一直是全球公共卫生保健的主要威胁，特别是在伤口愈合受损和生物医学植入物污染的情况下。在伤口护理管理中迫切需要开发具有所需抗微生物性质的新材料以避免和治疗伤口感染。本研究报道了一种新型的双功能可生物降解葡聚糖-聚乙二醇（PEG）水凝胶，其与抗菌多粘菌素B和万古霉素（Vanco）共价偶联。这种水凝胶被设计成一种专门的伤口敷料，可以根除现有的细菌并抑制细菌的进一步生长，同时改善抗生素的副作用，加速组织修复和再生。该水凝胶对革兰氏阴性细菌大肠杆菌（E.大肠杆菌）和革兰氏阳性菌金黄色葡萄球菌（S.金黄色葡萄球菌），对小鼠成纤维细胞系NIH 3 T3没有可观察到的毒性。这些结果证明了葡聚糖-PEG水凝胶作为伤口敷料医疗保健材料在复杂生物系统中有效控制细菌生长的巨大潜力。
Microbial infections continually present a major worldwide public healthcare threat, particularly in instances of impaired wound healing and biomedical implant fouling. The development of new materials with the desired antimicrobial property to avoid and treat wound infection is urgently needed in wound care management. This study reports a novel dual-functional biodegradable dextran-poly(ethylene glycol) (PEG) hydrogel covalently conjugated with antibacterial Polymyxin B and Vancomycin (Vanco). The hydrogel is designed as a specialized wound dressing that eradicates existing bacteria and inhibits further bacteria growth, while, ameliorating the side effects of antibiotics and accelerating tissue repair and regeneration. The hydrogel exhibits potent antibacterial activities against both gram-negative bacteria Escherichia coli (E. coli) and gram-positive bacteria Staphylococcus aureus (S. aureus) with no observable toxicity to mouse fibroblast cell line NIH 3T3. These results demonstrate the immense potential of dextran-PEG hydrogel as a wound dressing healthcare material in efficiently controlling bacteria growth in complex biological systems.