Neuron‒Mast Cell Cross-Talk in the Skin.
Neuron‒Mast Cell Cross-Talk in the Skin.
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DOI：
10.1016/j.jid.2021.10.006
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发表时间：
2021-11
期刊：
影响因子：
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通讯作者：
Shiqun Zhang;T. Sumpter;D. Kaplan
中科院分区：
文献类型：
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作者：
Shiqun Zhang;T. Sumpter;D. Kaplan
皮肤驻留肥大细胞（MC）和皮肤感觉神经元在微生物宿主防御和炎症性疾病中都发挥着至关重要的作用。 MC 可以被病原体或其产物直接激活，从而释放大量促进先天免疫反应并激活感觉神经元的介质。皮肤感觉神经元还可以直接检测病原体的存在，从而释放调节 MC 功能的神经肽。在这篇综述中，我们将重点关注皮肤感觉神经元和 MC 之间的相互作用以及这种相互作用在皮肤疾病中的重要性。
Skin-resident mast cells (MCs) and cutaneous sensory neurons both play crucial roles in microbial‒host defense and inflammatory diseases. MCs can be directly activated by pathogens or their products, resulting in the release of numerous mediators that promote innate immune responses and also activate sensory neurons. Cutaneous sensory neurons can also directly detect the presence of pathogens, resulting in the release of neuropeptides that modulate MC function. In this review, we will focus on the reciprocal interactions between cutaneous sensory neurons and MCs and the importance of this cross-talk in skin diseases.