Prevention of pancreatic cancer.
Prevention of pancreatic cancer.
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DOI：
10.5114/wo.2016.63043
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Szajda SD
中科院分区：
文献类型：
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作者：
Kuroczycki-Saniutycz S;Grzeszczuk A;Zwierz ZW;Kołodziejczyk P;Szczesiul J;Zalewska-Szajda B;Ościłowicz K;Waszkiewicz N;Zwierz K;Szajda SD
胰腺导管腺癌（PDA）占所有胰腺癌的95%。全世界每年约有23万例PDA病例被诊断出来。与其他癌症相比，PDA的五年生存率最低。在波兰，PDA是继肺癌、胃癌、结肠癌和乳腺癌之后的第五大死亡原因。在我们的论文中，我们分析了最新的流行病学研究，其中一些是有争议的，以建立在健康人群中预防胰腺癌的最佳实用解决方案，以及对已诊断为胰腺癌的患者的治疗。我们发现动脉导管未闭发生率很高，但通常诊断得太晚，处于晚期。除了遗传性疾病或慢性胰腺炎的高危人群外，PDA的筛查还没有很好的定义。我们提出了与胰腺癌相关的令人信服的，可能的和提示性的危险因素，其中许多是可以改变的，应该在我们的社会中引入和实施。
Pancreatic ductal adenocarcinoma (PDA) accounts for 95% of all pancreatic cancers. About 230,000 PDA cases are diagnosed worldwide each year. PDA has the lowest five-year survival rate as compared to others cancers. PDA in Poland is the fifth leading cause of death after lung, stomach, colon and breast cancer. In our paper we have analysed the newest epidemiological research, some of it controversial, to establish the best practical solution for pancreatic cancer prevention in the healthy population as well as treatment for patients already diagnosed with pancreatic cancer. We found that PDA occurs quite frequently but is usually diagnosed too late, at its advanced stage. Screening for PDA is not very well defined except in subgroups of high-risk individuals with genetic disorders or with chronic pancreatitis. We present convincing, probable, and suggestive risk factors associated with pancreatic cancer, many of which are modifiable and should be introduced and implemented in our society.