Psychotropic drugs as behavioral teratogens.
Psychotropic drugs as behavioral teratogens.
复制标题
精神药物作为行为致畸剂。
作者：
C. Vorhees;R. L. Brunner;R. Butcher
三种精神药物被注射给怀孕的大鼠，然后评估它们对后代的行为和生殖影响。对照组大鼠接受了生理盐水或维生素A。丙氯哌嗪对生殖和生长的干扰最大，但对行为的影响最小。丙氧酚对生殖或生长没有明显影响，但产生了各种行为变化。芬氟拉明对繁殖和生长的影响是中等的，在断奶前发育试验中显示出行为影响。数据表明，系统的行为测试为生殖毒性评估增加了重要信息，目前无法通过其他方式获得这些信息。
Three psychotropic drugs were administered to pregnant rats and were then evaluated for their behavioral and reproductive effects in the offspring. Control rats received either saline or vitamin A. Prochlorperazine had the most disruptive effects on reproduction and growth, but had the least effect on behavior. Propoxyphene had no apparent effects on reproduction or growth, but produced a variety of behavioral changes. Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development. The data suggest that systematic tests of behavior add important information to evaluations of reproductive toxicity that cannot, at present, be obtained by other means.