Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing
Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing
复制标题
小脑皮层突触多泡释放：其机制及其在神经编码和处理中的作用
作者：
S. Satake;Tsuyoshi Inoue;K. Imoto
在快速释放过程中释放的突触小泡的数量在决定突触后反应的强度中起着主要作用。然而，它仍然没有解决如何在一个单一的突触控制响应动作电位释放的囊泡的数量。最近的研究表明，Cav2.1亚型（P/Q型）的电压门控钙通道是负责诱导突触前多泡释放（MVR）在大鼠小脑颗粒细胞的分子层中间神经元的突触。从Cav2.1通道到胞吐Ca 2+传感器的地形距离是MVR的关键决定因素。在突触前神经元的生理训练中，MVR不仅通过增加突触后电流的峰值幅度，而且通过延长突触后电流的衰减时间来显著影响突触后神经元的兴奋性。因此，MVR为小脑皮质的神经编码和处理提供了额外的复杂性。
The number of synaptic vesicles released during fast release plays a major role in determining the strength of postsynaptic response. However, it remains unresolved how the number of vesicles released in response to action potentials is controlled at a single synapse. Recent findings suggest that the Cav2.1 subtype (P/Q-type) of voltage-gated calcium channels is responsible for inducing presynaptic multivesicular release (MVR) at rat cerebellar glutamatergic synapses from granule cells to molecular layer interneurons. The topographical distance from Cav2.1 channels to exocytotic Ca2+ sensors is a critical determinant of MVR. In physiological trains of presynaptic neurons, MVR significantly impacts the excitability of postsynaptic neurons, not only by increasing peak amplitude but also by prolonging decay time of the postsynaptic currents. Therefore, MVR contributes additional complexity to neural encoding and processing in the cerebellar cortex.
影响因子：
5.5
作者：
Bornschein, Grit;Arendt, Oliver;Schmidt, Hartmut
通讯作者：
Schmidt, Hartmut
小脑篮细胞的光学显微镜、共焦激光扫描显微镜、扫描和透射电子显微镜。
DOI：
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发表时间：
2001
期刊：
Journal of submicroscopic cytology and pathology.
影响因子：
--
作者：
Castejon,OJ;Castejon,HV;Sims,P
通讯作者：
Sims,P