Subtyping: What It Is and Its Role in Precision Medicine
Subtyping: What It Is and Its Role in Precision Medicine
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DOI：
10.1109/mis.2015.60
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发表时间：
2015-07-01
影响因子：
6.4
通讯作者：
Goldenberg, Anna
中科院分区：
文献类型：
--
作者：
Saria, Suchi;Goldenberg, Anna
精准医疗是一种新兴的方法，它考虑了基因、环境和生活方式的变化，以便更好地治疗个体。本文概述了不同的亚型分型方法，从早期的帐户基于临床实践的最近的方法，重点是计算派生的亚型的分子和电子健康记录（EHR）数据。这一领域是广阔的，增长迅速;作者并列不同社区采取的方法，并强调了重要的开放计算问题的例子。
Precision medicine is an emerging approach that considers variability in genes, environment, and lifestyle in order to better treat individuals. This article gives an overview of the diverse approaches to subtyping, from early accounts based on clinical practice to more recent approaches that focus on computationally derived subtypes based on molecular and electronic health record (EHR) data. This field is expansive and growing rapidly; the authors juxtapose approaches taken by different communities and highlight examples of significant open computational problems.