The role of the corpus striatum in neuroleptic- and narcotic-induced catalepsy.
The role of the corpus striatum in neuroleptic- and narcotic-induced catalepsy.
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纹状体在抗精神病药和麻醉药引起的僵直症中的作用。
DOI：
10.1016/0014-2999(78)90377-1
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发表时间：
1978
影响因子：
5
通讯作者：
O. Hornykiewicz
中科院分区：
文献类型：
--
作者：
K. Koffer;S. Berney;O. Hornykiewicz
损毁实验(在大鼠中)旨在阐明纹状体在抗精神病药和麻醉剂诱导的惊厥中的功能。观察双侧纹状体损毁以减轻神经麻痹(CPZ)诱导的迟发性麻痹。然而，纹状体的类似损伤加强了麻醉剂(吗啡)诱导的惊厥。这些结果提示：(A)纹状体可能是抗精神病药(如CPZ)产生过敏性麻痹的主要作用部位，(B)麻醉剂(吗啡)诱导的过敏性过敏症可能不完全由纹状体介导。
Lesion experiments (in the rat) were designed to elucidate the function of the corpus striatum in neuroleptic- and narcotic-induced catalepsy, respectively. Bilateral lesions of the corpus striatum were observed to attenuate neuropleptic (CPZ)-induced catalepsy. However, analogous lesions of the corpus striatum potentiated narcotic (morphine)-induced catalepsy. These results suggests that (a) the corpus striatum may be a primary site of action of neuroleptic drugs (such as CPZ) in the production of catalepsy, and (b) narcotic (morphine)-induced catalepsy may not be exclusively mediated by the corpus striatum.