Cytochemical localisation of calcium ATPase activity during the erythrocytic cell cycle of Plasmodium falciparum
Cytochemical localisation of calcium ATPase activity during the erythrocytic cell cycle of Plasmodium falciparum
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DOI：
10.1016/s0020-7519(01)00189-8
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发表时间：
2001-06-01
影响因子：
4
通讯作者：
Wasserman, M
中科院分区：
文献类型：
--
作者：
Caldas, ML;Wasserman, M
Using a cytochemical technique, we evaluated the levels of Ca2+-ATPase activity in the plasmatic and in the parasitophorous vacuole membrane through the different developmental stages of the Plasmodium falciparum parasitised erythrocyte. We found that the activity is detectable and remains unaltered in the plasma membrane throughout the 48 h cell cycle. However, in the parasitophorous membrane, although the activity was very similar to that measured in the plasma membrane of the young stages (younger than 20-h-old parasites), it diminished gradually with maturation and in schizonts it was almost undetectable. These data suggest that the plasma membrane Ca2+ - ATPase is important in the maintenance of a low erythrocyte cytoplasmic Ca2+ concentration. and that in addition it could be a way to supply the vital cation to the parasite at the beginning of the infection, when other transport mechanisms have not yet developed. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
