Recurrence of renal cell carcinoma more than 5 years after nephrectomy
Recurrence of renal cell carcinoma more than 5 years after nephrectomy
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DOI：
10.1046/j.1442-2042.2002.00418.x
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发表时间：
2002-01-01
影响因子：
2.6
通讯作者：
Tsukamoto, T
中科院分区：
文献类型：
--
作者：
Uchida, K;Miyao, N;Tsukamoto, T
目的：探讨肾切除术后5年以上肾细胞癌(RCC)的临床特点及复发预测因素。方法：回顾分析239例肾细胞癌患者的临床资料。为了确定影响肾切除术后5年以上复发(延迟复发)的因素及其临床转归，我们采用Cox比例风险模型和生存研究进行多因素分析。结果：57例患者术后5年内复发(早期复发)，11例患者延迟复发。多因素分析显示，114例肾切除术后存活5年以上且无早期复发的患者，其临床和病理特征对延迟复发没有影响。结论：虽然延迟复发在肾癌患者中并不少见，但初治时的临床病理因素均不能预测其复发。对于原发灶术后5年以上无复发的患者，应仔细随访是否有延迟复发。
Objectives: We evaluated clinical features and predictive factors for the recurrence of renal cell carcinoma (RCC) developing more than 5 years after nephrectomy.Methods: retrospectively reviewed 239 patients with RCC who underwent surgery for the primary lesion. To identify factors that affected recurrence more than 5 years after nephrectomy (delayed recurrence) and its clinical outcomes, we performed a multivariate analysis using Cox's proportional hazards model and a survival study.Results: Recurrence developing within 5 years after nephrectomy (early recurrence) was found in 57 patients and delayed recurrence in 11 patients. The multivariate analysis revealed no clinical and pathologic features influencing delayed recurrence in 114 patients who survived more than 5 years after nephrectomy without having early recurrence. The patients with delayed recurrence showed better clinical outcomes than those with early recurrence when the rate was determined from the time of recurrence.Conclusions: Although delayed recurrence is not a rare event for patients with RCC, no clinical and pathologic factors at the time of the initial treatment can predict the recurrence. Patients who are free of recurrence for more than 5 years after surgery for a primary lesion should be carefully followed up for delayed recurrence.