Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma
Family History and Risk of Second Primary Breast Cancer after In Situ Breast Carcinoma
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DOI：
10.1158/1055-9965.epi-17-0837
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发表时间：
2018-03-01
影响因子：
3.8
通讯作者：
Li, Christopher I.
中科院分区：
文献类型：
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作者：
Baglia, Michelle L.;Tang, Mei-Tzu C.;Li, Christopher I.
背景：由于乳房X线摄影术的广泛应用，原位乳腺癌的发病率增加。关于为什么一些患有原位乳腺癌的女性后来发展为第二原发性乳腺癌，我们知之甚少。方法：在这项基于人群的巢式病例对照研究中，原位乳腺癌幸存者包括539例第二原发性乳腺癌患者和994例匹配对照，我们评估了乳腺癌一级家族史与发展为第二原发性乳腺癌风险之间的关系。结果：乳腺癌一级家族史与既往有原位乳腺癌的女性发生第二原发性乳腺癌的风险增加相关[比值比（OR）= 1.33，95%置信区间（CI），1.05-1.69]，而有两个或更多一级亲属受累的女性发生第二原发性乳腺癌的风险更高（OR = 1.94; 95%CI，1.15-3.28）。亲属在50岁以下被诊断为第二原发性乳腺癌的可能性更大（OR = 1.78; 95%CI，1.24-2.57）。与受影响的亲属的数量或年龄相关的风险没有差异，观察绝经status.Conclusions：从这项研究的结果表明，乳腺癌的第一学位家族史可能是一个重要的危险因素，发展中国家的第二原发性乳腺癌的妇女与以前的原位乳腺癌。(C)2018年AACR。
Background: Incidence rates of in situ breast carcinomas have increased due to widespread adoption of mammography. Very little is known about why some women with in situ breast cancer later develop second primary breast cancers.Methods: In this population-based nested case-control study among in situ breast cancer survivors, including 539 cases with a second primary breast cancer and 994 matched controls, we evaluated the association between first-degree family history of breast cancer and risk of developing a second primary breast cancer.Results: First-degree family history of breast cancer was associated with an increased risk of developing a second primary breast cancer among women with a previous in situ breast cancer [odds ratio (OR) = 1.33, 95% confidence interval (CI), 1.05-1.69] and those with two or more affected first-degree relatives had an even higher risk (OR = 1.94; 95% CI, 1.15-3.28). Those whose relative was diagnosed at less than 50 years old were more likely to develop a second primary breast cancer (OR = 1.78; 95% CI, 1.24-2.57). No difference in risks associated with number or age of affected relatives was observed by menopausal status.Conclusions: Results from this study suggest that first-degree family history of breast cancer may be an important risk factor for development of a second primary breast cancer among women with a previous in situ breast cancer. (C) 2018 AACR.