Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus
Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus
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DOI：
10.1016/j.cmet.2006.09.004
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发表时间：
2006-10-01
期刊：
影响因子：
29
通讯作者：
Nakazato, Masamitsu
中科院分区：
文献类型：
--
作者：
Date, Yukari;Shimbara, Takuya;Nakazato, Masamitsu
Ghrelin是一种胃肠道肽，在外周给药时刺激进食。阻断迷走神经传入通路可消除生长素释放肽诱导的进食，表明迷走神经传入通路可能是将促食欲生长素释放肽信号传递到大脑的途径。在这里，我们证明了外周ghrelin信号，至少部分通过迷走神经到达孤束核（NTS），增加下丘脑弓状核中的去甲肾上腺素（NA），从而至少部分通过α-（1）和β-（2）去甲肾上腺素能受体刺激进食。此外，双侧中脑横断喙的NTS，或毒素诱导的损失，在后脑神经元表达多巴胺β羟化酶（NA合成酶），废除ghrelin诱导的喂养。这些发现提供了新的证据，去甲肾上腺素能系统是必要的中枢控制摄食行为的外周给药生长激素释放肽。
Ghrelin, a gastrointestinal peptide, stimulates feeding when administered peripherally. Blockade of the vagal afferent pathway abolishes ghrelin-induced feeding, indicating that the vagal afferent pathway may be a route conveying orexigenic ghrelin signals to the brain. Here, we demonstrate that peripheral ghrelin signaling, which travels to the nucleus tractus solitarius (NTS) at least in part via the vagus nerve, increases noradrenaline (NA) in the arcuate nucleus of the hypothalamus, thereby stimulating feeding at least partially through alpha-(1) and beta-(2) noradrenergic receptors. In addition, bilateral midbrain transections rostral to the NTS, or toxin-induced loss of neurons in the hindbrain that express dopamine beta hydroxylase (an NA synthetic enzyme), abolished ghrelin-induced feeding. These findings provide new evidence that the noradrenergic system is necessary in the central control of feeding behavior by peripherally administered ghrelin.