A Hill type model of rat medial gastrocnemius muscle that accounts for shortening history effects
A Hill type model of rat medial gastrocnemius muscle that accounts for shortening history effects
复制标题
DOI：
10.1016/s0021-9290(98)00048-7
复制
发表时间：
1998-06-01
影响因子：
2.4
通讯作者：
Huijing, PA
中科院分区：
文献类型：
--
作者：
Meijer, K;Grootenboer, HJ;Huijing, PA
本研究的目的是开发一个希尔型肌肉模型，占缩短历史的影响。为此，推导出一个函数，该函数将力的下降与起始长度、缩短幅度和收缩速度相关联。通过大鼠内侧腓肠肌（GM）的短程等速实验确定历史参数。用新模型和标准Hill型模型进行了等速和等渗实验的模拟。将模拟结果与大鼠GM的实验结果进行比较，以评估是否纳入历史效应导致模型预测的改进。与实验结果相一致，新模型定性描述了等速缩短期间和之后的力减少，以及实验观察到等张收缩的等长终点在比完全等长长度-力曲线预期的更高的肌肉长度处获得。因此，与标准模型相比，新模型对实验结果给出了更好的定量预测。结果表明，加入历史效应可以大大提高Hill型模型的预测能力。该模型的适用性条件以外的其他本文中所描述的进行了讨论。(C)1998爱思唯尔科技有限公司版权所有。
The aim of the present study was to develop a Hill type muscle model that accounts for the effects of shortening history. For this purpose, a function was derived that relates force depression to starting length, shortening amplitude and contraction velocity. History parameters were determined from short-range isokinetic experiments on rat medial gastrocnemius muscle (GM). Simulations of isokinetic as well as isotonic experiments were performed with the new model and a standard Hill type model. The simulation results were compared with experimental results of rat GM to evaluate if incorporation of history effects leads to improvements in model predictions. In agreement with the experimental results, the new model qualitatively described force reduction during and after isokinetic shortening as well as the experimental observation that isometric endpoints of isotonic contractions are attained at higher muscle lengths than is expected from the fully isometric length-force curve. Consequently, the new model gave a better quantitative prediction of the experimental results compared to the standard model. It was concluded that incorporation of history effects can improve the predictive power of a Hill type model considerably. The applicability of the model to conditions other than those described in the present paper is discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.