A High-Throughput Assay of Cell-Surface Interactions using Topographical and Chemical Gradients
A High-Throughput Assay of Cell-Surface Interactions using Topographical and Chemical Gradients
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DOI：
10.1002/adma.200801942
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发表时间：
2009-01-19
影响因子：
29.4
通讯作者：
Alexander, Morgan R.
中科院分区：
文献类型：
--
作者：
Yang, Jing;Rose, Felicity R. A. J.;Alexander, Morgan R.
正交润湿性和地形梯度的组合样品格式制作使用等离子体聚合物涂层的微槽表面。优选的8细胞增殖在形貌和化学的特定组合上发现。这项概念验证研究证明了这种样品格式在高通量方式下研究细胞反应的多种表面特性之间的关系方面的潜在应用。
Orthogonal wettability and topographical gradients in a combinatorial sample format are fabricated using plasma-polymer-coated microgrooved surfaces. Preferred 8 cell proliferation is found on specific combinations of topography and chemistry. This proof-of-concept study demonstrates the potential applications of this sample format for investigating the relationship between multiple surface properties on cellular response in a high-throughput manner.