Correlation of major histocompatibility complex with opportunistic infections in simian immunodeficiency virus-infected rhesus monkeys.
Correlation of major histocompatibility complex with opportunistic infections in simian immunodeficiency virus-infected rhesus monkeys.
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发表时间：
1997-10
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通讯作者：
G. Baskin;R. Bontrop;H. Niphuis;R. Noort;J. Rice;J. Heeney
中科院分区：
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作者：
G. Baskin;R. Bontrop;H. Niphuis;R. Noort;J. Rice;J. Heeney
主要组织相容性复合体（MHC）在艾滋病发病机制中的作用是复杂的，因为病毒，宿主和环境中的复合变量。利用猴免疫缺陷病毒（猴免疫缺陷病毒）诱导的恒河猴（Macaca mulatta）艾滋病实验动物模型，可以控制重要变量。我们研究了MHC类型是否会影响个体猴子出现的机会性感染。发现了几种相关性，例如，巨细胞病毒与Mamu-B6密切相关（p < 0.001），而隐孢子虫与Mamu-DR 3密切相关（p < 0.001）。我们还发现，有一个机会性感染的风险增加了另一个。
The role of the major histocompatibility complex (MHC) in the pathogenesis of AIDS is complex because of compounding variables within the virus, host, and environment. Important variables can be controlled by using the experimental animal model of AIDS induced by simian immunodeficiency virus in rhesus monkeys (Macaca mulatta). We studied whether the MHC type influenced which opportunistic infections arose in an individual monkey. Several associations were found. For example, cytomegalovirus was strongly associated with Mamu-B6 (p < 0.001), whereas Cryptosporidium was associated strongly with Mamu-DR3 (p < 0.001). We also found that having one opportunistic infection increased the risk of having another.